Bradley T. Andresen, PhD
Assistant Professor of Pharmaceutical Sciences
College of Pharmacy
Phone: 909 469-8483 |
Hope College 1998
Unversity of Pittsburgh 2002
Dr. Andresen’s research interests are focused on G protein-coupled receptors (GPCRs) within the cardiovascular system. He studies two independent events: Angiotensin II signaling within renal vascular smooth muscle cells, which are proposed to be involved in hypertension; and the molecular mechanism of GPCR kinase 4 gamma (GRK4γ)-mediated inhibition of Gs-coupled receptors, polymorphisms in GRK4γ are implicated in hypertension. Dr. Andresen is also interested in GPCR research in general and is interested in deorphanizing GPCRs; he is currently working on identifying the C-peptide receptor.
Andresen BT. A pharmacological primer of biased agonism. Endocr Metab Immune Disord Drug Targets 11:92, 2011.
Andresen BT. Characterization of G protein-coupled receptor kinase 4 and measuring its constitutive activity in vivo. Methods Enzymol. 484:631, 2010.
Luo Z, Chen Y, Chen S, Welch WJ, Andresen BT, Jose PA, and Wilcox CS. Comparison of drugs to inhibit superoxide generation in vascular smooth muscle cells. Br. J. of Pharmacol. 157:935, 2009.
Nordquist L, Palm F, Andresen BT. Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action. Biologics: Targets & Therapy 2:441, 2008.
Escano CS, Keever LB, Gutweiler AA, Andresen BT. Angiotensin II Activates ERK Through a Non-Receptor Tyrosine Kinase Dependent Mechanism in Renal Smooth Muscle Cells: Implications for Blood Pressure Regulation. J Pharmacol Exp Ther. 324:34-42, 2008.