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Bradley T. Andresen, PhD, FAHA


Assistant Professor of Pharmaceutical Sciences

College of Pharmacy

E-Mail: bandresen@westernu.edu

Phone: (909) 469-8483 | Fax: (909) 469-5600
Join year: 2011

Education

BS
Hope College 1998

PhD
Unversity of Pittsburgh 2002

Postdoc
NIH 2004

Research Interest

 Dr. Andresen’s research interests are focused on G protein-coupled receptors (GPCRs) within the cardiovascular system.  He studies two independent events: Angiotensin II signaling within renal vascular smooth muscle cells, which are proposed to be involved in hypertension; and the molecular mechanism of GPCR kinase 4 gamma (GRK4γ)-mediated inhibition of Gs-coupled receptors, polymorphisms in GRK4γ are implicated in hypertension.  Dr. Andresen is also interested in GPCR research in general and is interested in deorphanizing GPCRs; he is currently working on identifying the C-peptide receptor.

Publication

Erickson CE, Gul R, Blessing CP, Nguyen J, Liu T, Pulakat L, BastepeM, Jackson EK, and Andresen BT.  The β-blocker Nebivolol is a GRK/β-arrestin Biased Agonist.  PLoS ONE 8(8): e71980, 2013. doi:10.1371/journal.pone.0071980.

Nistala R, Pulakat L, Andresen BT, Sinak C, Mandavia C, Thekkumkara T, Speth R, Whaley-Connell A, and Sowers J. Angiotensin Type 1 Receptor Resistance To Blockade In The Opossum Proximal Tubule Cell Due To Variations In The Binding Pocket. Am J Physiol Renal Physiol 304:F1105, 2013.

Le IP, Schultz S, Andresen BT, Dewey GL, Zhao P, Listenberger L, Deen PM, Buchwalter A, Barney CC, and Burnatowska Hledin MA. Aquaporin-2 Levels in vitro and in vivo are Regulated by VACM-1, a cul 5 Gene. Cell. Phys. and Biochem. 30:1148, 2012.

Johnson A*, Le IP*, Andresen BT*, Stodola J, Dewey GL, Dean SB, Resau J, Haak P, Ruch T, Sartor A, Lazdins I, Barney CC, and Burnatowska Hledin MA. VACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations. Cell Tissue Res. 349:527, 2012. (* co-first authors)

Andresen BT. A pharmacological primer of biased agonism. Endocr Metab Immune Disord Drug Targets 11:92, 2011.

Zhang N, Andresen BT, and Zhang C. Inflammation and Reactive Oxygen Species in Cardiovascular Disease. World J Cardiol. 2:408, 2010.

Andresen BT. Characterization of G protein-coupled receptor kinase 4 and measuring its constitutive activity in vivo. Methods Enzymol. 484:631, 2010.

Yang Y, Andresen BT, Yang K, Li X, Li X, and Zhang Y. Association of VEGF -634C/G polymorphism, plasma level of VEGF, and diabetic retinopathy in type 2 diabetic Han Chinese. Exp Biol Med. 235:1204, 2010.

Luo Z, Chen Y, Chen S, Welch WJ, Andresen BT, Jose PA, and Wilcox CS. Comparison of drugs to inhibit superoxide generation in vascular smooth muscle cells.  Br. J. of Pharmacol. 157:935, 2009.


Nordquist L, Palm F, Andresen BT. Renal and vascular benefits of C-peptide: Molecular mechanisms of C-peptide action. Biologics: Targets & Therapy 2:441, 2008.


Escano CS, Keever LB, Gutweiler AA, Andresen BT.  Angiotensin II Activates ERK Through a Non-Receptor Tyrosine Kinase Dependent Mechanism in Renal Smooth Muscle Cells: Implications for Blood Pressure RegulationJ Pharmacol Exp Ther. 324:34-42, 2008.