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Chandrashekhar (Chandru) Charavaryamath, BVSc, MVSc, PhD


Instructor, Veterinary Anatomy and Histology

College of Veterinary Medicine

E-Mail: ccharavaryamath@westernu.edu

Phone: 3806 | Join year: 2012

Education

Post Doctoral Fellowship: Vaccine and Infectious Disease Organization (VIDO, www.vido.org),  and Department of Pathology,

Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada

PhD: Mechanisms of lung inflammation, Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Canada

MVSc:  Veterinary Microbiology, Veterinary College, University of Agricultural Sciences, Bangalore, India

BVSc (DVM):Veterinary College, University of Agricultural Sciences, Bangalore, India

Professional Experience

I. Anti Infective Drug Discovery Research Experience (1999-2002): Dr. Reddy’s Research Foundation (currently Aurigene Discovery Technologies Ltd.) Hyderabad, India.

a. Pre-Clinical Efficacy Profiling of Anti-Infective Novel Chemical Entities

b. Development of in vitro screening and profiling assay: MIC, MBC, PK/PD models

c. Development of in vitro screening and profiling model: LD50, ED50 and animal models of infection

d. Culture and screening methods for fastidious and anaerobic organisms

II. Toxicology and Safety Evaluation of NCEs

1. Performed Ames Test using Salmonella reference strains to detect the mutagenicity of NCEs.

2. Necropsy procedures and clinical hematology procedures for laboratory animals.

III. Veterinary Care to the laboratory animals

4. Provided routine health care to the laboratory animals (small rodents, rabbits and Beagle dogs)

3. Received training in, Microbiological Animal Health Monitoring at National Center for Laboratory Animal Sciences, NIN, Hyderabad, India.

2. Microbiological Monitoring of Air and Water quality of Research Centre.

1. Surgical Aspiration of Bone Marrow in Beagle dogs for anti-cancer drug cytotoxicity studies

Veterinary Clinical Practice Experience

1. Veterinarian (1999-2002), Dr. Reddy’s Research Foundation, Hyderabad, India

2. Veterinarian (1997-1999), Small Animal Practice, Bangalore, India

3. Intern (6 months, 1997): Veterinary College Teaching Hospital, University of Agricultural Sciences, Bangalore, India

4. Clinical veterinary microbiology training during my MVSc degree (1997-1999).

 

Academic Interests

Development of Anatomical Teaching Models

Teaching Experience

Teaching experience:

1. Laboratory Instruction in Veterinary Anatomy, Histology and Embryology (April 2012-current)

2. Teaching assistant (TA) in Veterinary Gross Anatomy, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon (2004-2006)

3. Facilitator for Veterinary Biomedical Rounds course, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon

Other teaching experiences:

1. Worked as a a visiting faculty in Microbiology for BITS, Pilani, for their MSc (off-campus) Program in Hyderabad, India

 

Courses

Laboratory sessions (Veterinary Anatomy and Histology) of VBS course

Philosophy

"If you give a man a fish you feed him for a day. If you teach a man to fish you feed him for a lifetime."- Chinese proverb.

Research Interest

1. Mechanisms of lung inflammation and pattern recognition receptors

2. Animal models of Mycobacterium avium subspecies paratuberculosis

3. Mucosal Immunity and host-pathogen interactions

4. Novel methods of reducing microbial load (alternative to antibiotics usage) in farm animals

Awards

Scholarships/Fellowships:

1. Public Health and the Agricultural Rural Ecosystem (PHARE) graduate training grant (CIHR and University of Saskatchewan, Canada) (2005-2008).

2. Veterinary Biomedical Sciences Departmental Graduate Tuition Award (2005-2008).

3. Founding Chairs PhD Scholarship from University of Saskatchewan, Saskatoon (2004-2005).

4. PhD Merit Scholarship, College of Graduate Studies and Research, University of Saskatchewan, Saskatoon (2002-2004).

5. Government of India National Merit Scholarship during Highschool and BVSc (DVM) (1990-1997).

 

Awards and Distinctions:

1. Pfizer Animal Health Graduate Student Research Award, September 2006.

2. American Association of Veterinary Anatomist poster presentation (2006): 1st and 3rd prize

3. Travel Award, Immunology Research Group, University of Saskatchewan, Saskatoon, 2006.

4. Cecil E. Doige Travel Award, University of Saskatchewan, Saskatoon, 2004 and 2005.

5. American Association of Anatomists Travel Award (January 2004)

6. College of Graduate Studies and Research Travel Award, University of Saskatchewan, 2004 and 2005.

7. University of Saskatchewan President Fund Student Award, 2004 and 2005.

8. Merial Canada best poster award, University of Saskatchewan, Saskatoon, Canada, 2004.

Organizations

1. Member, Scientific Affairs Committee, American Association of Anatomist (AAA): 2011-2014

2. Member, American Association of Anatomist (AAA): 2008-2012

3. Member, American Association of Veterinary Anatomist (AAVA): 2008-2012

Publication

1. Charavaryamath C, Gonzalez-Cano P, Fries P, Gomis S, Doig K, Scruten E, Potter A, Napper S, Griebel PJ: Host Responses to Persistent Mycobacterium avium subspecies paratuberculosis infection in surgically isolated bovine ileal segments. Clinical and vaccine immunology. 2012 Dec 5.

2. Duke-Novakovski T, Singh-Suri S, Kajikawa O, Caldwell S, Charavaryamath C, Singh B: Immuno-phenotypic and functional characterization of rabbit pulmonary intravascular macrophages. Cell and tissue research 2012 (epub ahead of print).

3. El-Hadi M, Charavaryamath C, Aebischer A, Smith CW, Shmon C, Singh B: Expression of interleukin-8 and intercellular cell adhesion molecule-1 in the synovial membrane and cranial cruciate ligament of dogs after rupture of the ligament. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 2012, 76(1):8-15.

4. Janardhan KS, Charavaryamath C, Aulakh GK, Singh B: Integrin beta3 is not critical for neutrophil recruitment in a mouse model of pneumococcal pneumonia. Cell and tissue research 2012, 348(1):177-187.

5. Charavaryamath C, Fries P, Gomis S, Bell C, Doig K, Guan LL, Potter A, Napper S, Griebel PJ: Mucosal changes in a long-term bovine intestinal segment model following removal of ingesta and microflora. Gut microbes 2011, 2(3):134-144.

6. Charavaryamath C, Lemieux H, Singh Suri S, Selvakumar P, Sharma RK, Singh B: Expression and activities of N-myristoyltransferase and calcineurin in normal and inflamed lungs. Experimental lung research 2009, 35(9):729-747.

7. Charavaryamath C, Keet T, Aulakh GK, Townsend HG, Singh B: Lung responses to secondary endotoxin challenge in rats exposed to pig barn air. J Occup Med Toxicol 2008, 3:24.

8. Charavaryamath C, Juneau V, Suri SS, Janardhan KS, Townsend H, Singh B: Role of Toll-like receptor 4 in lung inflammation following exposure to swine barn air. Experimental lung research 2008, 34(1):19-35.

9. Gamage LN, Charavaryamath C, Swift TL, Singh B: Lung inflammation following a single exposure to swine barn air. J Occup Med Toxicol 2007, 2:18.

10. Shrivastav A, Sharma AR, Bajaj G, Charavaryamath C, Ezzat W, Spafford P, Gore-Hickman R, Singh B, Copete MA, Sharma RK: Elevated N-myristoyltransferase activity and expression in oral squamous cell carcinoma. Oncology reports 2007, 18(1):93-97.

11. Charavaryamath C, Janardhan KS, Caldwell S, Singh B: Pulmonary intravascular monocytes/macrophages in a rat model of sepsis. The anatomical record Part A, Discoveries in molecular, cellular, and evolutionary biology 2006, 288(12):1259-1271.

12. Lakshmikuttyamma A, Selvakumar P, Charavaryamath C, Singh B, Tuchek J, Sharma RK: Expression of calcineurin and its interacting proteins in epileptic fowl. Journal of neurochemistry 2006, 96(2):366-373.

13. Charavaryamath C, Singh B: Pulmonary effects of exposure to pig barn air. J Occup Med Toxicol 2006, 1:10.

14. Selvakumar P, Lakshmikuttyamma A, Charavaryamath C, Singh B, Tuchek J, Sharma RK: Expression of myristoyltransferase and its interacting proteins in epilepsy. Biochemical and biophysical research communications 2005, 335(4):1132-1139.

15. Charavaryamath C, Janardhan KS, Townsend HG, Willson P, Singh B: Multiple exposures to swine barn air induce lung inflammation and airway hyper-responsiveness. Respiratory research 2005, 6:50.

16. Selvakumar N, Srinivas D, Khera MK, Kumar MS, Mamidi RN, Sarnaik H, Charavaryamath C, Rao BS, Raheem MA, Das J et al: Synthesis of conformationally constrained analogues of linezolid: structure-activity relationship (SAR) studies on selected novel tricyclic oxazolidinones. Journal of medicinal chemistry 2002, 45(18):3953-3962.

17. Charavaryamath C, Puttabyatappa B, Krishnappa G and Venkatesha MD. Bacteriological aspects of canine pyoderma in Canines. INTAS POLYVET 2: 100-102, 2001.

18. Charavaryamath C, Puttabyatappa B, Krishnappa G and Umesh KG. Immunological aspects staphylococcal pyoderma in canines. Indian Journal of Comparative Microbiology, Immunology and Infectious Diseases 22: 67-68, 2001.

Note: Publications # 17 and 18 above are not listed in PubMed (reprints available).