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Fadi T. Khasawneh, PhD, B.Pharm


Associate Professor of Pharmaceutical Sciences

College of Pharmacy

E-Mail: fkhasawneh@westernu.edu

Phone: 909-706-3738 | Join year: 2008

Education

Ph.D.
2007 University of Illinois at Chicago

B. Pharm
1999 Jordan University of Science and Technology

 

Research Interest

My research is focused on the study of thrombosis and platelet biology. Our primary goal is to delineate signaling pathways involved in platelet activation and to investigate their role in the pathogenesis of thrombotic diseases. We employ a host of molecular, biochemical and pharmacological approaches, as well as an in vivo Carotid Artery Thrombosis model in our studies. Our ultimate goal is to identify novel therapeutic targets for the management of thromboembolic disorders.
 

Research Grant

Investigation of Platelet G-protein Coupled Receptors

National Institutes of Health, NHLBI, 1R15HL115567-01A1

Principal Investigator

$416,976 (2013-2016)

Publication

Srinivasan, S., Mir, F., Huang, J., Khasawneh, F.T., Lam, S.C., and Le Breton, G.C.,“The P2Y12 Antagonists, 2-Methylthioadenosine 5’-Monophosphate Triethylammonium Salt and Cangrelor (ARC69931MX), Can Inhibit Human Platelet Aggregation through a Gi-independent Increase in cAMP Levels,” J. Biol. Chem., Vol. 284 (24), 16108-16117, 2009.

 

Ting H.J., and Khasawneh, F.T.,Glybenclamide: an antidiabetic with in vivo antithrombotic activity”. Eur. J. Pharmacol, 649, 249–254, 2010.

 

Murad J.P., Ting H.J., Espinosa E.V.P., and Khasawneh, F.T., “The C-terminal Segment of the Second Extracellular Loop of the Thromboxane A2 Receptor Plays an Important Role in Platelet Aggregation” Biochemical Pharmacology, Vol. 83, 88-96, 2012

 

Espinosa E.V.P., Murad J.P., Ting H.J., and Khasawneh, F.T., “Mouse Transient Potential Channel 6: Role in Hemostasis and Thrombogenesis”, Biochem Biophys Res Commun., 2012; 417 (2), 853–856

 

Murad J.P., Lin O.A., Espinosa E.V.P., and Khasawneh, F.T., “Current and Experimental Antibody-Based Therapeutics: Insights, Breakthroughs, Setbacks and Future Directions.”Curr. Mol. Med., 2013 1;13(1):165-78.