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Jijun Hao, PhD


Assistant Professor, Stem Cell Biology / Cancer Biology

College of Veterinary Medicine

E-Mail: jhao@westernu.edu

Phone: 909-469-8686 | Join year: August, 2012

Education

PhD.  Department of Biochemistry & Molecular Biology, University of Leeds, Leeds, UK, 2003

BSc.  Department of Biochemical Enginering, East China University of Science and Technology, Shanghai, China, 1996

Professional Experience

Research Assistant Professor, Vanderbilt University Medical Center, Nashville, TN, USA, 2010-2012

Research Fellow,  Vanderibilt University Medical Center, Nashville, TN, USA, 2004-2010

Academic Interests

Stem cell biology, zebrafish-based drug screening and cancer biology.

Research Interest

My current research mainly focuses on 1) chemical approaches for stem cell/iPS cell cardiomyogenesis, 2) zebrafish-based drug screening, and 3) cancer biology.

By zebrafish-based screening, we have identified a number of small molecules which can modulate key signaling pathways such as BMP, Wnt/β-catenin and Hedgehog pathways. As these key signaling pathways are involved in stem cell fate decisions and many types of human diseases including cancer, the small molecules that modulate these key pathways may control stem cell differentiation as well as serve leads for cancer drug development. 

Organizations

American Heart Association
 

Committees


Western University of Health Sciences Research Committee,                  2013 ~ Present

Research Advisory Committee, College of Veterinary Medicine,              2012 ~ Present

Instructional Resource Committee,  College of Veterinary Medicine,        2012 ~ Present

Publication

  Articles

 Hao, J*., Lee, R., Chang, A., Fan, J., Labib C., Parsa, C, Orlando, R., Andresen, B. and Huang, Y* (2014) "DMH1, A Small Molecule Inhibitor of BMP Type I Receptors, Suppresses Growth and Invasion of Lung Cancer", PLoS ONE  9(3): e90748.(*corresponding author).

Hao J*., Galindo CL, Tran TL and Sawyer DB*. (2014)  "Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors". Biochemical Journal  458, 335-341, (*corresponding author)

Sheng, CC, Hao, J. and Hong, CC. (2014) “Chemically Induced Pluripotent Stem Cells (CiPSCs): A Potential Chemical Biological Breakthrough in Reprogramming?” John Wiley & Sons Inc. ISBN: 978-1-118-34959-5. (In press)

 Hong, CC, Ao, A. and Hao, J. (2014) Book: "Chemical Biology in Regenerative Medicine: Bridging Stem Cells and Future Therapies  , John Wiley & Sons Inc (in process).

Han, G.F., Wang, H.T., and Hao, J.* (2013) "Molecular Mechanisms of Embryonic Stem Cell Pluripotency", Pluripotent Stem Cells", INTECH press, ISBN 978-953-51-1192-4(*corresponding author).

Hao, J, Ao, A, Zhou, L, Murphy, CK, Frist, AY, Keel, JJ, Throne, CA,Kim, K, Lee,E and Hong,CC. (2013) "Selective Small Molecule Targeting beta-Catenin Function Discovered by In Vivo Chemical Genetic Screen", Cell Reports, 4, 898-904

Sheng, CC., Zhou, L. and Hao, J.* (2013) “Current Stem Cell Delivery Methods for Myocardial Repair”, BioMed Research International (formerly titled Journal of Biomedicine and Biotechnology), Article ID 547902 (*corresponding author)

Ao A, Hao J, Hopkins CR and Hong CC. (2012) “DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells”, PLoS One, 7, e41627

Wiley, DM., Kim, JD, Hao, J., Hong, CC., Bautch, VL., Jin, SK. (2011) “Distinct signaling pathways regulate sprouting angiogenesis from the dorsal aorta and axial vein” Nature Cell Biology, 13,686–692

Hao, J*,Sawyer, DB., Hatzopoulos, AK and Hong,CC (2011) “Recent progress on chemical biology of pluripotent stem cell: self-renewal, reprogramming and cardiomyogenesis”, Recent Patents on Regenerative Medicine, 1, 263-274, (*corresponding author)

Ao, A., Hao, J, Hong, CC. (2011) “Regenerative chemical biology: current challenges and future potentials”, Chemistry & Biology, 18, 413-424

Wang, H., Hao, J*, Hong, CC. (2011) “Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signalling”, ACS Chemical Biology, 6, 192–197, (*co-first author and co-corresponding author)

Ao, A, Williams, CH, Hao, J*, Hong, CC. (2011) “Modified mouse embryonic stem cell based assay for quantifying cardiogenic induction efficiency”,J Vis Exp., 50, 2656. (*co-corresponding author)

Hao, J., Zhou, L., Hong, CC. (2011) “Chemical biology of pluripotent stem cells: Focus on cardiomyogenesis”, Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine, INTECH, ISBN: 978-953-307-1985, 51-64

Hao,J., Daleo, MA and Hong, CC. (2010) “Crosstalk between mitogen activated protein kinase and phosphoinositide-3 kinase signalling pathways in development and disease”, Systems Biology for Signaling Networks, , Springer, New York, ISBN:978-144-195-7962, 505-529

Hao, J, Williams, C H., Webb, M E., Hong, CC. (2010) “Large scale zebrafish-based in vivo small molecule screen”, J. Vis. Exp., 46, 2243

Hao, J, Ho, JN, Lewis, JA, Karim, K, Daniels, RN, Gentry, PR, Hopkins, CR, Lindsley, CW and Hong CC. (2010) “In vivo structure activity relationship study of dorsomorphin analogs identifies selective VEGF and BMP inhibitors”,ACS Chemical Biology, 5, 245–253

Hao,J., Daleo MA, Murphy, CK, Yu, PB, Ho, JN, Hu J, Peterson, RT., Hatzopoulos, AK., Hong, CC. (2008) “Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells”, PLoS ONE, 3, e2904

Hao, J., Vann, WF., Hinderlich, S. and Sundaramoorthy, M. (2006)“Elimination of 2-keto-3-dexoy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation”, Biochem. J. 397, 195-201

Hao, J., Balagurumoorthy, P., Sarilla, S. and Sundaramoorthy, M. (2005)“Cloning, expression and characterization of sialic acid synthases”, Biochem. Biophys. Res. Comm. 338,1507-1514

Hao, J.and Berry, A. (2004) “A thermostable variant of fructose bisphosphate aldolase constructed by directed evolution also shows increased stability in organic solvents”, Protein Eng, Des and Sel. 17, 689-697

 

Patents

Hong, CC. Hao, J., Ao, A. and Kwangho, K., “Compounds and methods for inhibition of wnt signaling”, US patent application No: US 61/508,919 (pending).

Hong, CC. Hao, J., Frist, A., Williams, CH., “Compounds and methods for inhibition of hedgehog signaling”, US patent application No: US 61/524,428 (pending).

Hong, CC., Hopkins, C R., Hatzopoulos, AK., Lindsley, CW and Hao, J.“Compounds and methods useful for directing stem cell differentiation”, US patent application No:12/537,037 (pending)

 

Selected Achievements

1) Developed DMH1, a small molecule inhibitor of BMP signalling.  

http://www.sigmaaldrich.com/catalog/product/sigma/d8946?lang=en&region=US

2) Developed DMH4, a small molecule inhibitor of VEGF signaling.

http://www.sigmaaldrich.com/catalog/product/sigma/d8696?lang=en®ion=US

3) Discovered Windorphen, a small molecule inhibitor of Wnt/beta-catenin signaling

http://www.sigmaaldrich.com/catalog/product/sigma/sml0899?lang=en®ion=US