Kabir Lutfy, PhD, M.Sci., B.Pharm
Professor of Pharmaceutical Sciences
College of Pharmacy
Phone: 909-469-5481 |
1996 University of California, Irvine
1990 St. John's University
1980 Kabul University - Kabul, Afghanistan
Kabirullah Lutfy - Associate Professor of Pharmaceutical Sciences
University of California, Irvine
St. John's University
Kabul University - Kabul, Afghanistan
Description of Academic/Research Interests:
Using a combination of behavioral and neurochemical approaches, our laboratory is interested in determining the role of the neuropeptide orphanin FQ/nociceptin (OFQ/N) and its receptor, the opioid receptor-like (ORL-1) receptor, in:
(1) Cocaine sensitization
(2) Buprenorphine's actions to alter pain perception and the function of the mesolimbic dopaminergic reward circuitry.
(3) Opioid tolerance
We are also interested in determining the role of endogenous opioid peptides/receptors system in stress-mediated increases in drug use and abuse.
Khaliq IA, Farasat S, Ackerson L, Lutfy K. Cocaine fails to elevate pallidal glutamate in rats sensitized to cocaine, Pharmacologyonline, 2005, 1, 154-176.
Lutfy K, Cowan A. Buprenorphine: A unique drug with complex pharmacology. Current Neuropharmacology, 2004, 2, 395-402.
Narayanan S, Lam H, Carroll FI, Lutfy K. Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats. Journal of Psychiatry & Neuroscience, 2004, 29, 116-123.
Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminijad N, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by µ-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. Journal of Neuroscience, 2003, 23, 10331-10337.
Lutfy K, Khaliq I, Carroll FI, Maidment NT. Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats. Psychopharmacology, 2002, 164, 168-176.