Ph.D.
1996 University of California, Irvine

M. Sci
1990 St. John's University

B. Pharm
1980 Kabul University - Kabul, Afghanistan

 

Kabirullah Lutfy - Associate Professor of Pharmaceutical Sciences


Degree
Year
obtained
Institution
Ph.D.
1996
University of California, Irvine

M. Sci
1990
St. John's University

B. Pharm
1980
Kabul University - Kabul, Afghanistan

 

Description of Academic/Research Interests:
Using a combination of behavioral and neurochemical approaches, our laboratory is interested in determining the role of the neuropeptide orphanin FQ/nociceptin (OFQ/N) and its receptor, the opioid receptor-like (ORL-1) receptor, in:

(1) Cocaine sensitization
(2) Buprenorphine's actions to alter pain perception and the function of the mesolimbic dopaminergic reward circuitry.
(3) Opioid tolerance

We are also interested in determining the role of endogenous opioid peptides/receptors system in stress-mediated increases in drug use and abuse.

Khaliq IA, Farasat S, Ackerson L, Lutfy K. Cocaine fails to elevate pallidal glutamate in rats sensitized to cocaine, Pharmacologyonline, 2005, 1, 154-176.

Lutfy K, Cowan A. Buprenorphine: A unique drug with complex pharmacology. Current Neuropharmacology, 2004, 2, 395-402.

Narayanan S, Lam H, Carroll FI, Lutfy K. Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats. Journal of Psychiatry & Neuroscience, 2004, 29, 116-123.

Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminijad N, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ. Buprenorphine-induced antinociception is mediated by µ-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. Journal of Neuroscience, 2003, 23, 10331-10337.

Lutfy K, Khaliq I, Carroll FI, Maidment NT. Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats. Psychopharmacology, 2002, 164, 168-176.