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Michel Baudry,




Graduate College of Biomedical Sciences

E-Mail: mbaudry@westernu.edu

Phone: 8271 |

Education

Engineer Degree 1971

Ecole Polytechnique
Paris, France
Master Degree in Biochemistry 1972

 

University Paris VII
Paris, France
PhD Biochemistry (cum laude) 1977

 

University Paris VII
Paris, France

Education Experience

1978-80 Postdoctoral Research Assoc UCI & CNRS Fellow

Professional Experience

1972-73 Stagiaire de Recherches, National Center for Scientific Research (CNRS)

1973-76 Attache de Recherches CNRS

1976-78 Charge de Recherches CNRS

1/81-6/81 Assist. Research Psychobiologist UCI

7/81-6/82 Assist. Research Psychobiologist & Adjunct Lecturer UCI

6/82-6/84 Assist. Professor-in-Residence UCI

7/84-6/89 Assoc. Professor-in-Residence UCI

9/88-6/89 Visiting Scientist, Genentech Inc., South San Francisco, CA

1989-1993 Associate Professor, University of Southern California

Dept. of Biology - Section of Neurobiology

1993-2011 Professor, USC, Dept. of Biology-Section of Neurobiology, Department of Neurology, USC Medical School, Department of Biomedical Engineering, USC.

2001- 2003: Visiting Professor, Department of Psychiatry & Human Behavior, UCI, CA

2001-2003: VP Research, Tensor Biosciences, Irvine, CA

2012- Professor and Dean, Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA

Academic Interests

Neuroscience

Computational Biology

Advanced Courses

Teaching Experience

UCI:
Psychobiology: 1984-1987.

 

USC:
BISC306: Human Physiology
BISC 421: Neurobiology
BISC 524: Neuroscience
BISC221: Advanced General Biology
Special Topics in Neuroscience
BISC104: Introduction to Physiology for non-biology majors
BISC230Lg: Brain, Mind and Machines: Topics in Neuroscience

Research Interest

  1. Mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions.
  2. Regulation of glutamate receptors.
  3. Role of oxygen free radicals in central nervous system.
  4. Mechanisms underlying selective neuronal degeneration.
  5. Computational neuroscience

Research Grant

Current Research Support:

- PI: NINDS (R01): “Simulation of learning: models and biological validation”. 02/02/09-01/31/2013.

- Co-Investigator: NINDS (P01): “BDNF and Spine-Related Disorders of Memory and Cognition”. (PI: Dr. Christine Gall). 09/01/09-08/31/2016.

- PI: NeuralStem. “Efficacy of NSI cell implantation to the limbic system following the development of chronic mTLE in the rat”. 03/01/2012-02/28/2013.

Awards

Pfizer Lecture, Institut de Recherches Cliniques de Montreal. Canada, December 1984.

Doctor Honoris Causa, University of Provence, Marseille, France, 2010.

USC Mellon Excellence Award for mentoring graduate students, April 2010.

Organizations

American Neuroscience Society

International Society of Neurochemistry

ISI Highly Cited Researchers

Fellow of the World Innovation Foundation

Committees

Panel member: NSF " Molecular and Cellular Neurobiology ", 1983-1985.

Panel Member: NIH: NSD-B Study Section, 2005-2009.

Panel Member: NIH-Fogarty International, 2008-present.

Panel Member: NIH: F02 Review Panel, 2008-present.

Publication

Lynch, G. and Baudry, M.  The biochemistry of memory: A new and specific hypothesis.  Science. 224: 1057-1063, 1984.

Morris, R.G.M., Anderson, E., Lynch, G.S. and Baudry, M.  Selective impairment of learning and blockade of long-term potentiation by N-methyl-D-aspartate receptor antagonist, AP-5.  Nature 319: 774-776, 1986.

Massicotte, G., Vanderklish, P., Lynch, G., and Baudry, M.  Modulation of AMPA/quisqualate receptors by phospholipase A2: A necessary step in long-term potentiation?  Proc. Nat. Acad. Sci.(USA)  88: 1893-1897, 1991.

Bruce, A., Malfroy, B. and Baudry, M.  ß-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic oxygen free radical scavenger. Proc. Nat. Acad. Sci.  93: 2312-2316, 1996.

Musleh, W., Bi, X., Tocco, G., Yaghoubi, S. and Baudry, M.  Glycine-induced long-term potentiation is associated with structural and functional modifications of AMPA receptors. Proc. Nat. Acad. Sci. 94: 9451-9456, 1997.

Rong, Y., Tocco, G., Doctrow, S. and Baudry, M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc. Nat. Acad. Sci. 96: 9897-9902, 1999.

Bi, R., Broutman, G., Foy, M., Thompson, R.F. and Baudry, M. The tyrosine kinase and MAP kinase pathways mediate multiple effects of estrogen in hippocampus. Proc. Nat. Acad. Sci. 97: 3602-3607, 2000.

Bi, R., Foy, M. R., Vouimba, R.-M., Thompson, R.F. and Baudry, M. Cyclic changes in estrogen regulate synaptic plasticity through the MAP kinase pathway. Proc. Nat. Acad. Sci. 98: 13391:13395, 2001.

 

Liu, R., Liu, Y., Bi, X., Thompson, R.F., Doctrow, S.R., Malfroy, B. and Baudry, M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase.catalase mimetics. Proc. Nat. Acad. Sci. 100: 8527-8531, 2003.

 

Zhou, M. and Baudry, M. Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. J. Neurosci. 26: 2956-2963, 2006.

 

Xu, W., Wong, T.P., Chery, N., Gaertner, T., Wang, Y.T.and Baudry,M. Calpain-mediated truncation of mGluR1a: a key step in excitotoxicity. Neuron, 53: 399-412, 2007.

 

Dominguez, R., Hu, E., Zhou, M. and Baudry, M. 17ß-estradiol-mediated neuroprotection and ERK activation require a pertussis toxin-sensitive mechanism involving GRK2 and ß-arrestin-1. J. Neurosci. 29: 4228-4238, 2009.

 

Jourdi, H., Hsu, Y.-T., Zhou, M., Qin, Q., Bi, X. and Baudry, M. Positive AMPA receptor modulation rapidly stimulates dendritic mRNA translation through BDNF release. J. Neurosci. 29: 8688-8697, 2009.

 

Zadran, S., Jourdi, H., Rostamiani, K., Qin, Q., Bi, X. and Baudry, M. BDNF- and EGF-mediated neuronal calpain activation through MAPK-dependent phosphorylation. J. Neurosci. 30: 1086-1095, 2010.

 

Zadran, S., Qin, Q., Bi, X., Zadran, H., Kim, Y., Foy, M.R., Thompson, R.F., and Baudry, M. 17-ß-estradiol increases neuronal excitability through MAP kinase-induced calpain activation. Proc. Nat. Acad. Sci. USA 106: 21936-21941, 2009.

 

Baudry, M., Bi, X., Gall, C. and Lynch, G. The biochemistry of memory: the 26-year journey of a new and specific hypothesis. Neurobiol. Learning & Memory 95: 125-133, 2011.

 

Clausen, A., Xu, X., Bi, X. and Baudry, M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s disease: Protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J. Alz. Dis. (in press).