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Nissar Darmani, PhD


Associate Dean for Basic Sciences
and Research; Chair of BMS;
Professor of Pharmacology


College of Osteopathic Medicine of the Pacific

E-Mail: ndarmani@westernu.edu

Phone: 909-469-5654 | Join year: 2005

Education

Ph.D., Neuropharmacology, University of Wales, UWIST, U.K., 1988
M.S., Applied Pharmacology, University of Wales, UWIST, U.K., 1984
Medical Scientific Officer, Immunohematology Center, Cambridge, UK, 1979-1983
B.S., Honors: Pharmacology & Biochemistry, Leeds University, England, U.K., 1979

Education Experience

Postdoctoral Fellow, Neuropsychopharmacology, Department of Pharmacology, Medical College of Virginia, 1988-1991

Teaching Experience

Associate Dean of BMS and Research, Western University of Health Sciences, COMP, 2011-present
Assistant Dean of BMS and Research, Western University of Health Sciences, COMP, 2008-2011
Chair, Department of Basic Medical Sciences, Western University of Health Sciences, COMP 2005-present
Professor, Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO, 2000-2005
Associate Professor, Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO, 1995-2000
Assistant Professor, Department of Pharmacology, Kirksville College of Osteopathic Medicine, Kirksville, MO, 1991-1995
Research Assistant Professor, Department of Pharmacology, Medical College of Virginia, 1991

Courses

Dr. Darmani's main training has been in the field of pharmacology and will be teaching the core pharmacology course involving introduction to pharmacology, pharmacodynamics and pharmacokinetics.

Research Interest

Dr. Darmani has several avenues of research interest that include:

  • Developmental effects of drugs of abuse on the newborn.
  • Serotonergic mechanisms of cocaine's actions.
  • Mode of action of antidepressant drugs.
  • Adaptive mechanisms of serotonergic 5-HT2 receptor functions.
  • The role of delta-9 -THC and synthetic cannabinoids on chemotherapy- and radiotherapy-induced vomiting. His laboratory had the first opportunity to demonstrate the mechanisms of antiemetic actions of marijuana.
  • Role of 5-HT3-, Dopamine D2/3-, Lekotriene CysLT1- and NK1- receptors in emesis and application of their antagonists as antiemetics.
  • Another of his research interests involves the role of osteopathic manipulative medicine on the blood levels of endogenous cannabinoid-like compounds and other pain markers in patients with back pain. He had been successful in obtaining several million dollars of research grants from numerous funding agencies including the Pharmaceutical industry, the National Institute of Drug Abuse, the National Institute of Cancer, the Department of Defense and the Environmental Protection Agency.

Publication

Recent Publications:

  • Darmani NA, Zhong W, Chebolu S, Alkam T. (2013) Broad-spectrum antiemetic potential of the L-type calcium channel antagonist nifedipine and evidence for its additive antiemetic interaction with the 5-HT3 receptor antagonist palonosetron in the least shrew (Cryptotis parva). Eur. J. Pharmacol. (in press).
  • Darmani NA, Chebolu S. (2013) The role of endocannabinoids and arachidonic acid metabolites in emesis. In: Endocannabinoids: Molecular, pharmacological, behavioral and clinical features:(Murillo-Rodriguez, E.; Onaive, E.S.; Darmani, N.A. and Wagner,E. eds. Bentham e Books, Chapter 2, pp 25-59.
  • Darmani NA. (2013) New vistas in the pathophysiology of vomiting. Family Medicine Medical Science Res. 2:1. http//dx.doi.org/10.4172/fmmer.1000e105.
  • Darmani NA, Dey D, Chebolu S, Amos B, Kandpal R. (2013) Cisplatin causes over-expression of neurokinin NK1 receptors and increases ERK1/2- and PKA-phosphorylation during peak immediate- and delayed-phase emesis in the least shrew (Cryptotis parva) brainstem. Eur. J. Pharmacol. 698: 161-169.
  • Al-Tikriti MS, Khamas W, Chebolu S, Darmani NA. (2012) Distribition of serotonin-immunoreactive chromaffin cells in the gastrointestinal tract of the least shrew (Cryptotis parva). Int. J. Morphology 30: 916-923.
  • Darmani NA, Chebolu S, Amos B, Alkam T. (2011) Synergistic interactions between serotonergic 5-HT(3) and tachykininergic NK(1)-receptor antagonists in the least shrew (Cryptotis parva). Pharmacol Biochem Behav. 99: 573-579.
  • Tiwari V, Darmani NA, Yue BY, Shukla D. (2010) In vitro antiviral activity of neem (Azardirachta indica L.) bark extract against herpes simplex virus type-1 infection. Phytother Res 24: 1132-1140.
  • Darmani NA. (2010) Cannabinoid-induced hyperemesis: a conundrum- from clinical recognition to basic science mechanisms. Pharmaceuticals 3: 21-63-2177. Doi10.3390/ph3072163 
  • Darmani NA. (2010) Mechanisms of broad-spectrum antiemetic efficacy of cannabinoids against chemotherapy-induced acute and delayed vomiting. Pharmaceuticals. Accepted pending minor changes. 
  • King KS, Darmani NA, Adams KT and Pacak K. (2010) Exercise-induced nausea and vomiting: Another sign of pheochromocytoma and paraganglioma. Endocrine 37: 403-407.
  • Hubbard S, Darmani NA, Thrush GR, Dey D, Burnham L., Thompson JM, Jones K, Tiwari V. (2010) Zebrafish-encoded 3-O-sulfotransferase-3 isoform mediates herpes simplex virus type 1 entery and spread. Zebrafish 7:181-187.
  • Chebolu S, Wang Y, Ray AP and Darmani NA. (2010) Pranlukast prevents Cysteinyl Leukotriene-induced Vomiting in the Least Shrew (Cryptotis parva). Eur. J. Pharmacol. 628:195-201. 
  • Dey D, Abad J, Ray AP and Darmani NA. (2010) Differential temporal changes in brain and gut substance P mRNA expression throughout the time course of cisplatin-induced vomiting in the least shrew (Cryptotis parva) Brain Res. 1310:103-112.
  • Hubbard S, Darmani NA, Thrush GR, Dey D, Burnham L., Thompson JM, Jones K, Tiwari V. (2010) Zebrafish-encoded 3-O-sulfotransferase-3 isoform mediates herpes simplex virus type 1 entery and spread. Zebrafish 7:181-187.

Click links below for additional publications and information:

http://www.ncbi.nlm.nih.gov/pubmed?term=Darmani%20NA

http://www.afghan-network.net/Culture/avicenna.html

http://whyfiles.org/225drug_receptors/