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Sebastien Fuchs, PhD


Assistant Professor of Pharmacology

College of Osteopathic Medicine of the Pacific

E-Mail: sfuchs@westernu.edu

Phone: 5232 | Join year: August 2013

Education

M.D., University Paris VI / European Hospital Georges Pompidou, Paris, France, 2003

Ph.D., University Paris VII / College de France, Paris, France, 2002

M.S., Biochemistry, University Paris V, Paris, France, 1993

Education Experience

Postdoctoral Fellowship, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 2002-2006

Predoctoral and Doctoral Training, Vascular Pathology and Renal Endocrinology, INSERM U36 – Collège de France, Paris, France, 1991-2002

Student rotation in Mouse Transgenesis, Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX, Summer 1994

Professional Experience

Academic Editor for PlosOne, 2012 – present

Teaching Experience

Assistant Professor of Pharmacology, Western University of Health Sciences, COMP, Dept. of BMS, 2013-present

Assistant Professor, Department of Biomedical Sciences and Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 2008-2012

Instructor, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 2006- 2008

Courses

Reproductive Pharmacology

Research Interest

 I am studying the biochemistry and physiology of Angiotensin-Converting Enzyme (ACE) in vivo in genetically modified animals. Beside blood pressure, ACE is involved in many other function including peptide presentation (immunology), extracellular matrix control (end-organ damages), male fertility, Alzheimer's disease.

My current areas of research are organ fibrosis (inflammation and extracellular matrix processing) and Alzheimer's disease.

I have acquired numerous scientific/technical skills (molecular biology: DNA manipulation, mutation, plasmid construction and analysis, animal genetic models, biochemistry, cellular biology, in vivo experimentation, animal physiology).

Research Grant

The CART Fund for Alzheimer Research. Award, 2012-2014
RO0 phase of NIH/NHLBI Pathway to Independence Award (K99/RO0 HL088000), 2008-2011
K99 phase of NIH/NHLBI Pathway to Independence Award (K99/RO0 HL088000), 2006-2008
Beginning Grant in Aid from the “American Heart Association” (0665176B), 2006-2008
Research fellowship from the “National Kidney Foundation”, 2004-2006
Grant for foreign post-doctoral fellowship from INSERM, 2002-2003
Grant fellowship from “Academie Nationale de medecine”, 2001-2002
Doctoral fellowship from the French Ministry for Scientific Research, 1998-2001
Predoctoral fellowship from “Fondation pour la Recherche Medicale”, 1997-1998
Fellowship for foreign training program from “Fondation pour la Recherche, Medicale”, 1994

Publication

 

Recent Publications

  • Gonzalez-Villalobos RA., Jandjoulia T., Fletcher NK., Giani JF., Nguyen MT., Riquier-Brison AD., Seth DM., Fuchs S., Eladari D., Picard N., Bachmann S., Delpire E., Peti-Peterdi J., Navar LG., Bernstein KE. and McDonough AA. The absence of intrarenal ACE protects against hypertension. J Clin Invest.2013, May 1;123(5):2011-2023
  • Bernstein KE., Ong FS., Blackwell WB., Shah KH., Giani JF., Gonzalez-Villalobos RA., Shen XZ., Fuchs S. A modern understanding of the traditional and non-traditional biological functions of angiotensin converting enzyme (ACE). Pharmacol Rev, 2012 Dec 20;65(1):1-46.
  • Shen XZ., Ong FS., Bernstein EA., Janjulia T., Blackwell WL., Shah KH., Taylor BL., Gonzalez-Villalobos RA., Fuchs S., Bernstein KE. Nontraditional roles of angiotensin-converting enzyme. Hypertens. 2012 Apr;59(4):763-8.
  • Ong FS., Lin CX., Campbell DJ., Okwan-Duodu D., Chen X., Blackwell WLB., Shah KH., Gonzalez-Villalobos RA., Shen, XZ. and Fuchs S., Bernstein KE. Increased angiotensin II induced hypertension and inflammatory cytokines in mice lacking angiotensin converting enzyme N-domain activity. Hypertens. 2012 Feb;59(2):283-90.
  • Bernstein KE, Shen XZ, Gonzalez-Villalobos RA, Billet S, Okwan-Duodu D, Ong FS, and Fuchs S. Different in vivo functions of the two catalytic domains of angiotensin converting enzyme (ACE). Curr Opin Pharmacol. 2011 Apr;11(2):105-11.
  • Gonzalez-Villalobos RA, Billet S, Kim C, Satou R, Fuchs S, Bernstein KE, and Navar LG. Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion. J Am Soc Nephrol. 2011 Mar;22(3):449-59.
  • Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, and Bernstein KE. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010 Dec 10;285(50):39051-60
  • Li P, Xiao HD, Xu J, Ong FS, Kwon M, Roman J, Gal A, Bernstein KE, and Fuchs S. Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury. Am J Pathol. 2010 Sep; 177 (3) :1113-21.

Invited Talks and Abstracts

  • S. Fuchs. “Angiotensin-Independent Functions of Angiotensin-Converting Enzyme” XX Brazilian Society Congress of Hypertension, August 2012, Sao Paulo, Brazil (invited speaker)
  • S. Fuchs, P. Li, RA. Gonzalez-Villalobos, KE. Bernstein. “Importance of the N-terminal site of angiotensin-converting enzyme and AcSDKP in the control of fibrosis” Gordon Research Conference, 2012 February 26 - March 2, 2012, Ventura, CA, (poster).
  • S. Fuchs, P. Li, RA. Gonzalez-Villalobos, KE. Bernstein. “The tetrapeptide SDKP protects from bleomycin-induced lung injury.” Gordon Research Conference, August 14-19, 2011, Newport, RI. (poster).
  • S. Fuchs “Importance of the N-terminal site of angiotensin-converting enzyme and AcSDKP in the control of fibrosis” Experimental Biology 2011, April 10, 2011, Washington DC, (invited speaker).
  • S. Fuchs “ACE inactivation to treat lung fibrosis? Lessons from animal models” BATSSS, April 7, 2010, Cedars-Sinai Medical Center, Los Angeles, CA. (poster).