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Stephen O'Barr, BS, PhD


Associate Professor and Chair Department of Pharmaceutical Sciences

College of Pharmacy

E-Mail: sobarr@westernu.edu

Phone: 909-469-5643 | Join year: 1999

Education

BS - Biochemistry/Cellular Biology 1992
University of California, San Diego, John Muir College
 

Ph.D. Molecular and Cellular Biology 1997
Arizona State University, Tempe

 

Research Interest

Hormone regulation of amyloid-beta precursor protein expression and processing. Characterization and modulation of neuroimmunologic pathologies in Alzheimer's disease brain. Expression and function of chemokine and complement anaphylatoxin molecules and receptors in the normal and diseased central nervous system. Cytokine expression and function in perpheral reactive arthropathies.
 

Publication

DiVall MV, Hayney MS,  Marsh W, Neville MW, O'Barr SA, Sheets ED, Calhoun LD. Perception of the students, faculty, and administrators on the use of technology in the classroom.  Am J Pharm Educ. 2013 May 13;77(4):75.

Wu-Pong S, O’Barr SA, Gobburu J, Shah K, Huber J, Weiner D.  The Future of the Pharmaceutical Sciences and Graduate Education.  Recommendations from the AACP Graduate Education Special Interest Group. Am J Pharm Educ. 2013 May 13;77(4):S2.

Chow SL, O'Barr SA, Peng J, Chew E, Pak F, Quist R, Patel P, Patterson JH, Heywood JT.Modulation of Novel Cardiorenal and Inflammatory Biomarkers by Intravenous Nitroglycerin and Nesiritide in Acute Decompensated Heart Failure: An Exploratory Study. Circ Heart Fail. 2011 May 16.

Chow SL, O'Barr SA, Peng J, Chew E, Pak F, Quist R, Patel P, Patterson JH, Heywood JT. Renal function and neurohormonal changes following intravenous infusions of nitroglycerin versus nesiritide in patients with acute decompensated heart failure. J Card Fail. 2011 Mar;17(3):181-7. Epub 2010 Dec 3.

O'Barr SA, Oh JS, Ma C, Brent GA, Schultz JJ. Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models.Thyroid. 2006 Dec;16(12):1207-13.
 
O'Barr SA, Caguioa J, Gruol D, Perkins G, Ember JA, Hugli T, Cooper NR "Neuronal expression of a functional receptor for the C5a complement activation fragment." J Immunol 166(6):4154-62 (2001)

O'Barr, S., Cooper, N.R. "Complement C5a increases IL-1ß and IL-6 release from Amyloid ß-primed THP-1 cells." J. Neuroimmunology 109(2):87-94 (2000)

Cooper, N.R., Bradt, B.M., O'Barr, S., Yu, J.X. "Focal Inflammation in the Brain: Role in Alzheimers Disease." Immunologic Research 21(2-3):159-165 (2000)

Rogers, J. and O'Barr, S. "Inflammatory mediators in Alzheimer's disease". In: Molecular Mechanisms of Dementia; Editors: W. Wasco & R.E. Tanzi, Humana Press Inc., Totowa N.J. pp 177-198 (1997)