Stephen O'Barr, BS, PhD
Associate Professor and Chair Department of Pharmaceutical Sciences
College of Pharmacy
E-Mail: sobarr@westernu.edu
Phone: 909-469-5643 |
Education
BS - Biochemistry/Cellular Biology 1992
University of California, San Diego, John Muir College
Ph.D. Molecular and Cellular Biology 1997
Arizona State University, Tempe
Research Interest
Hormone regulation of amyloid-beta precursor protein expression and processing. Characterization and modulation of neuroimmunologic pathologies in Alzheimer's disease brain. Expression and function of chemokine and complement anaphylatoxin molecules and receptors in the normal and diseased central nervous system. Cytokine expression and function in perpheral reactive arthropathies.
Publication
Chow SL, O'Barr SA, Peng J, Chew E, Pak F, Quist R, Patel P, Patterson JH, Heywood JT.Modulation of Novel Cardiorenal and Inflammatory Biomarkers by Intravenous Nitroglycerin and Nesiritide in Acute Decompensated Heart Failure: An Exploratory Study. Circ Heart Fail. 2011 May 16.
Chow SL, O'Barr SA, Peng J, Chew E, Pak F, Quist R, Patel P, Patterson JH, Heywood JT. Renal function and neurohormonal changes following intravenous infusions of nitroglycerin versus nesiritide in patients with acute decompensated heart failure. J Card Fail. 2011 Mar;17(3):181-7. Epub 2010 Dec 3.
O'Barr SA, Oh JS, Ma C, Brent GA, Schultz JJ. Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models.Thyroid. 2006 Dec;16(12):1207-13.
O'Barr SA, Caguioa J, Gruol D, Perkins G, Ember JA, Hugli T, Cooper NR "Neuronal expression of a functional receptor for the C5a complement activation fragment." J Immunol 166(6):4154-62 (2001)
O'Barr, S., Cooper, N.R. "Complement C5a increases IL-1ß and IL-6 release from Amyloid ß-primed THP-1 cells." J. Neuroimmunology 109(2):87-94 (2000)
Cooper, N.R., Bradt, B.M., O'Barr, S., Yu, J.X. "Focal Inflammation in the Brain: Role in Alzheimers Disease." Immunologic Research 21(2-3):159-165 (2000)
Rogers, J. and O'Barr, S. "Inflammatory mediators in Alzheimer's disease". In: Molecular Mechanisms of Dementia; Editors: W. Wasco & R.E. Tanzi, Humana Press Inc., Totowa N.J. pp 177-198 (1997)