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Yvonne Drechsler,


Assistant Professor Immunology and Virology

College of Veterinary Medicine

E-Mail: ydrechsler@westernu.edu

Phone: 3535 | Join year: 2007

Education

2001 PhD in Molecular Biology, Children's Hospital University Tübingen, Germany

1997 Dipl. Biol (equivalent to Masters Degree in Biology) University Tübingen, Germany

Professional Experience

2000-2003 Postdoctoral Fellowship at University of Massachusetts Medical Center, Worcester, MA

2004-2007 Postdocteral Fellowship at the Veterinary College Texas A&M University, College Station, Tx

Research Interest

My interests are innate immunity, specifically in response to viruses and the underlying genetic mechanisms of disease resistance or immunogenetics.

I am currently working on several projects including macrophage responses to avian influenza (AIV), infectious bronchitis virus (IBV) and feline infectious peritonitis virus (FIPV). We are looking at functional differences of macrophages in response to these viruses and what the genetic factors are influencing this response.

The avian system is a unique opportunity to study the role of the MHC complex in regards to disease resistance and susceptibility, because we can work with genetically well defined haplotypes.

The feline immune system is not well understood, particularly in response to FIPV, but the host response plays an important role and we are developing assays to analyze the role of feline macrophages better.

 

Research Grant

1.      Drechsler Yvonne, Collisson Ellen, Diniz Pedro, Bossong Frank, 2010-2012: Identifying Genetic Determinants Differentiating Feline Coronavirus and Peritonitis Virus Pathotypes, Morris Animal Foundation $108,000. (Primary Investigator)

2.      Drechsler Yvonne, 2010-2011: Genetic regions involved in Coronavirus Nephropathogenesis. Western University Intramural Grant $15000 (Primary Investigator).

3.     Collisson, E.W., PI, Drechsler Y, Barr M, Terra R, Gordon Ross P. (2010-2012) USDA Avian Influenza Cooperative Agricultural Program, Avian Influenza Education for Families with Backyard Poultry in Southern California. $83,915. (Co-PI)

4.     Collisson E.W., PI, Drechsler Y, Dawes M and Irizarry K. (2008-2011) USDA-NRI, Competitive grants program, “Impact of immune responses of chickens with defined B haplotypes on resistence to respiratory coronavirus infection.”  $375,000. (Co-PI).

5.       PI, Jill Adler Moore (Cal Poly), Collisson EW, Drechsler Y, 2010-2012State University Agricultural Research Initiative  “Combination liposomal and DNA vaccine technologies for development of non-infectious influenza vaccines for protecting poultry,” $150,000 (Co-Investigator)

6.      Collisson E.W. Drechsler Y: Surro Immune (Surro Immunology) 2010-2011. “Effects of caprine arthritis encephalitis virus on macrophage and T lymphocyte function,” $40,116. (Co-PI).

7.      Drechsler Y 2008-2009: Development of IBV as viral vectors for HA of avian influenza. Western University Intramural Grant $22000 (Primary Investigator).

8.       Collisson E.W. PI, Drechsler Y. 2006-2009Federal Wildlife Service, “Controlling for the REV Threat to the Endangered Attwater’s Prairie Chicken,”  $50,000/year for 5 years ($250,000). (Co-PI).

Organizations

American Society of Virology

Committees

Research Advisory Committee (CVM); Chair

Admissions Committee (CVM)
 

Publication

Drechsler Y, Alcaraz A, Bossong FJ, Collisson EW, Diniz PPVP. “ Feline Coronavirus in Multicat Environments” Vet Clin Small Anim 41 (2011) 1133–1169

Drechsler Y, Bohls RL, Smith R, Silvy N, Lillehoy H, Collisson EW: An avian, oncogenic retrovirus replicates in vivo in more than fifty percent of CD4+ and CD8+ T lymphocytes from an endangered grouse. Virology 386(2):380-6, 2009. Impact factor 3.2

Drechsler Y, Dolganiuc A, Norkina O, Romics L, Li W, Kodys K, Bach FH, Mandrekar P, Szabo G: Heme oxygenase-1 mediates the anti-inflammatory effects of acute alcohol on IL-10 induction involving p38 MAPK activation in monocytes. J Immunol 177(4): 2592-2600, 2006. Impact factor 6.0

Drechsler Y, Chavan S, Catalano D, Mandrekar P, Szabo G: FcgR crosslinking mediates NFKB activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development. Journal of Leukocyte Biology. 72(4):657-67, 2002. Impact factor 4.

Collisson EW, Singh S, Drechsler Y:  Evolving vaccine choices for the continuously evolving avian influenza viruses. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 3, No. 088, 2008.

Romics L, Mandrekar P, Kodys K, Velayudham A, Drechsler Y, Dolganiuc A, Szabo G: Increased lipopolysaccharide sensitivity in alcoholic fatty livers is independent of leptin deficiency and toll/like receptor 4 (TLR4) or TLR2 mRNA expression. Alcoholism: Clinical and Experimental Research. 29(6): 1018-1026, 2005.

Romics L, Dolganiuc A, Kodys K, Drechsler Y, Oak S, Velayudham A, Mandrekar P, Szabo G: Selective priming to Toll-like receptor 4 (TLR4), not TLR2, ligands by P. acnes involves up-regulation of MD-2 in mice. Hepatology. 40(3): 555-564, 2004.

Publications under my maiden name (Brockmann). Both publications by Neu S are actually my work from my PhD thesis, but at the time I was graduating the PI would frequently be the first author.

Gessler P. Neu S. Brockmann Y. Speer CP. Decreased mRNA expression of G-CSF receptor in cord blood neutrophils of term newborns: regulation of expression by G-CSF and TNF-alpha. Biology of the Neonate. 77(3):168-73, 2000.

Neu S, Brockmann Y, Grau R, Geiselhart A, Speer CP: KIR expression by neonatal and adult cytotoxic CD56+ cells. Pediatric Research. 44: 444, 1998.

Neu S, Geiselhart A, Brockmann Y, Speer CP: Immunomagnetic enrichment of neonatal and adult cytotoxic CD56+ cells. Pediatric Research. 44: 448, 1998.