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Ying Huang, PhD, Master of Medicine, MD


Associate Professor

College of Pharmacy

E-Mail: yhuang@westernu.edu

Phone: 909-469-5220 |

Education


PhD 2002
Ohio State University
 

Master of Medicine 1997
Institute of Virology, Chinese Academy of Preventive Medicine

M.D. 1994
Beijing Medical University

 

Research Interest

The overall goal of my research is to elucidate the genetic mechanisms by which tumors show differential response to anticancer drugs with the aim of developing strategies for preventing or overcoming resistance. My current area of research focuses on the pharmacogenomics of membrane transporters, which are responsible for drug absorption, distribution and targeting to tumor cells, and identifying their potential relevance to cancer chemotherapy. Another research goal is to identify the gender differences in the membrane transport of drugs and their contribution to inter-individual variation in drug actions using mRNA and protein profiling of transporters in human liver.

Publication

Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, LiVolsi L, Frankel W, Kloos RT, Eng C, Pellegata NS, and de la Chapelle A. Gene Expression in Papillary Thyroid Carcinoma Reveals Highly Consistent Profiles. Proc Natl Acad Sci U S A 2001 98: 15044-15049

Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN & Sadee W. Membrane Transporters and Channels: Role of the Transportome in Cancer Chemosensitivity and Chemoresistance. Cancer Research 2004, 64:4294-4301

Huang Y, Blower PE, Yang C, Barbacioru C, Dai Z, Zhang Y, Xiao J, Chan KK & Sadee W. Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1. The Pharmacogenomics Journal, 2005, 5: 112-125

Huang Y, Dai Z, Barbacioru C & Sadee W. The cystine/glutamate transporter SLC7A11 in cancer chemosensitivity and -resistance. Cancer Research 2005 Aug 15;65(16):7446-54

Huang Y and Sadee W. Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells. Cancer Letter (Invited review). 2006, 239:168-82