Dr. Darmani's main training has been in the field of pharmacology and will be teaching the core pharmacology course involving introduction to pharmacology, pharmacodynamics and pharmacokinetics.

Selected Publications:

Darmani, N. A.;McClanahan, B. A.; Trinh, C.; Petrosino, S.; Valenti, M. And Di Marzo, V. (2005) Cisplatin increases brain 2-arachidonoylglycerol (2-AG) and concomitantly reduces intestinal 2-AG and anandamide levels in the least shrew. Neuropharmacology 49:502-513.
 
Darmani, N. A.;  Izzo, A. A.; Degenhardt, B.; Valenti, M.; Scaglione, G.; Capasso, F.; Sorrentini, I. and  Di Marzo, V. (2005) Implication of the cannabimimetic mediator, palmitoylethanolamide, in inflammatory or neuropathic conditions: A review of the available pre-clinical findings and first clinical data. Neuropharmacology 48:1154-1163.

Mock, O.; Casteel, S.; Darmani, N.A.; Shaddy, J.; Kenneth, K.; Besch-Williford and Towns, L. (2005) 1,3-dinitrobenzene toxicity in the least shrew, Cryptotis parva. Environmental Toxicology and Chemistry. In press

Darmani, N.A. and Crim, J.L. (2005) Delta-9-tetrahydrocannabinol prevents emesis more potently than enhanced locomotor activity produced by chemically diverse dopamine D2/D3 receptor agonists in the least shrew (Cryptotis parva) Pharmacol. Biochem. Behav. 80:35-44. Darmani, N.A. and Johnson, J.C. (2004) Central and peripheral mechanisms contribute to the antiemetic actions of ?9-THC against 5-hydroxytryptophan-induced emesis. Eur. J. Pharmacol.  488: 201-212.

Dr. Darmani has several avenues of research interest that include: 

• developmental effects of drugs of abuse on the newborn
• serotonergic mechanisms of cocaine's actions
• mode of action of antidepressant drugs
• adaptive mechanisms of serotonergic 5-HT2   receptor functions
• the role of delta-9 -THC and synthetic cannabinoids on chemotherapy- and radiotherapy-induced  vomiting. His laboratory had the first opportunity to demonstrate the mechanisms of antiemetic actions of marijuana
• one of his more recent research avenues involves the role of osteopathic manipulative medicine on the blood levels of endogenous cannabinoid-like compounds and other pain markers in patients with back pain. He had been successful in obtaining several million dollars of research grants from numerous funding agencies including the Pharmaceutical industry, the National Institute of Drug Abuse, the National Institute of Cancer, the Department of Defense and the Environmental Protection Agency.

Darmani, N.A. (2004) Methods evaluating endocannabinoids and cannabinoid effects on gastrointestinal functions. In:Marijuana and cannabinoid research: Methods and protocols (Onaivi ES, editor) The Humana Press Inc. Totowa NJ, USA . (inpress).

Darmani, N.A. (2004) Endocannabinoids and gastrointestinal function.  In: Endocannabinoids: The brain and body's marijuana and beyond.  (Onaivi, ES; Sugiura, T. and DiMarzo, V. editors) CRC Press (in press). Darmani, N.A.  (2002) Antiemetic action of delta-9-tetrahydrocannabinoid and synthetic cannabinoids.  In: Biology of marijuana: From gene to behavior.  (Onaivi, ES, ed) Taylor and Francis Books Ltd., London, UK, Chapter 13, pp 356-389.