 Biographical Information
Stephen O'Barr- Associate Professor of Pharmaceutical Sciences
Director of Graduate Education
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Degree
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Year obtained
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Institution
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BS - Biochemistry/Cellular Biology
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1992
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University of California, San Diego, John Muir College
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Ph.D. Molecular and Cellular Biology
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1997
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Arizona State University, Tempe
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Description of Academic/Research Interests
Hormone regulation of amyloid-beta precursor protein expression and processing. Characterization and modulation of neuroimmunologic pathologies in Alzheimer's disease brain. Expression and function of chemokine and complement anaphylatoxin molecules and receptors in the normal and diseased central nervous system. Cytokine expression and function in perpheral reactive arthropathies.
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O'Barr SA, Oh JS, Ma C, Brent GA, Schultz JJ. Thyroid hormone regulates endogenous amyloid-beta precursor protein gene expression and processing in both in vitro and in vivo models.Thyroid. 2006 Dec;16(12):1207-13.
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O'Barr SA, Caguioa J, Gruol D, Perkins G, Ember JA, Hugli T, Cooper NR "Neuronal expression of a functional receptor for the C5a complement activation fragment." J Immunol 166(6):4154-62 (2001)
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O'Barr, S., Cooper, N.R. "Complement C5a increases IL-1ß and IL-6 release from Amyloid ß-primed THP-1 cells." J. Neuroimmunology 109(2):87-94 (2000)
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Cooper, N.R., Bradt, B.M., O'Barr, S., Yu, J.X. "Focal Inflammation in the Brain: Role in Alzheimers Disease." Immunologic Research 21(2-3):159-165 (2000)
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Rogers, J. and O'Barr, S. "Inflammatory mediators in Alzheimer's disease". In: Molecular Mechanisms of Dementia; Editors: W. Wasco & R.E. Tanzi, Humana Press Inc., Totowa N.J. pp 177-198 (1997)
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Contact Information
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| Office address: 309 E. Second St. |
| Pomona, CA 91766 |
| Main phone: (909) 469-5500 |
| Fax: (909) 469-5600 |
| E-mail: sobarr@westernu.edu |
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© 2009 Western University of Health Sciences. All Rights Reserved | 309 E. Second St. Pomona, CA 91766-1854 | (909) 623-6116 