 Biographical Information
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Degree
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Year
obtained
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Institution
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PhD
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2002
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Ohio State University
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Master of Medicine
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1997
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Institute of Virology, Chinese Academy of Preventive Medicine
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| M.D. |
1994
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Beijing Medical University
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Description of Academic/Research Interests:
The overall goal of my research is to elucidate the genetic mechanisms by which tumors show differential response to anticancer drugs with the aim of developing strategies for preventing or overcoming resistance. My current area of research focuses on the pharmacogenomics of membrane transporters, which are responsible for drug absorption, distribution and targeting to tumor cells, and identifying their potential relevance to cancer chemotherapy. Another research goal is to identify the gender differences in the membrane transport of drugs and their contribution to inter-individual variation in drug actions using mRNA and protein profiling of transporters in human liver. |
| Selected Publications |
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Huang Y, Prasad M, Lemon WJ, Hampel H, Wright FA, Kornacker K, LiVolsi L, Frankel W, Kloos RT, Eng C, Pellegata NS, and de la Chapelle A. Gene Expression in Papillary Thyroid Carcinoma Reveals Highly Consistent Profiles. Proc Natl Acad Sci U S A 2001 98: 15044-15049
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Huang Y, Anderle P, Bussey KJ, Barbacioru C, Shankavaram U, Dai Z, Reinhold WC, Papp A, Weinstein JN & Sadee W. Membrane Transporters and Channels: Role of the Transportome in Cancer Chemosensitivity and Chemoresistance. Cancer Research 2004, 64:4294-4301
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Huang Y, Blower PE, Yang C, Barbacioru C, Dai Z, Zhang Y, Xiao J, Chan KK & Sadee W. Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1. The Pharmacogenomics Journal, 2005, 5: 112-125
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Huang Y, Dai Z, Barbacioru C & Sadee W. The cystine/glutamate transporter SLC7A11 in cancer chemosensitivity and -resistance. Cancer Research 2005 Aug 15;65(16):7446-54
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Huang Y and Sadee W. Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells. Cancer Letter (Invited review). 2006, 239:168-82
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Contact Information
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Office address: 309 E. Second St.
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Pomona, CA 91766
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Main phone: (909) 469-5500
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Fax: (909) 469-5600
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E-mail: yhuang@westernu.edu
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© 2008 Western University of Health Sciences. All Rights Reserved | 309 E. Second St. Pomona, CA 91766-1854 | (909) 623-6116 