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 Tom R. Phillips, DVM, PhD - Research Interests

Portrait of Tom R. Phillips

  • Viral mRNA processing, Rev/RRE regulation
  • Lentivirus Astrocyte Interactions
  • FIV effects on the CNS
  • Effects of Drugs of Abuse on Disease Progression
  • Neurotoxicity/Oxidative Stress/Apoptosis
  • Stem cells
  • Vaccine Development

FIV Chart

Link to Phillips Research Powerpoint


FUNDED RESEARCH:

1. NIMH: MH47680 Aids Center Grant : "AIDS DEMENTIA: Molecular and Cellular Mechanisms"
  • Scientific Director: Floyd E. Bloom, M.D.
  • Principal Investigator: Tom R. Phillips (Research Supplement)
  • (Research Supplement) Title : FIV: A Lentivirus Model for Therapeutic Intervention.
  • Project Period: 09/01/93 - 08/31/95
  • Direct Yearly Costs: $127,183
  • Total Direct Costs: $254,367

2. NIMH: MH47680 Aids Center Grant : "AIDS DEMENTIA: Molecular and Cellular Mechanisms"
  • Scientific Director: Floyd E. Bloom
  • Principal Investigator - Research Component, Tom R. Phillips
  • Component Title: "FIV: A Lentivirus Model for CNS Therapeutics"
  • Project Period: 09/01/95 - 08/31/2000
  • Direct Yearly Costs (Component): $193,688
  • Total Direct Costs (Component): $968,442

3. NIH: 1R24RR10712 "Antiviral Effects on FIV Neurologic Disease Progression"
  • Principal Investigator: Tom R. Phillips
  • Project Period: 04/01/95 - 03/31/00
  • Direct Yearly Costs: $114,962
  • Total Direct Costs: $444,884

Four Images

4. NIH: 1R01DA10198 "FIV: A Lentivirus Model for Opiate Effects on Disease".
  • Principal Investigator: Tom R. Phillips
  • Project Period: 06/01/96 - 04/30/2000
  • Direct Yearly Costs: $223,002
  • Total Direct Costs: $892,008

5. NIH: 1R24RR10712-renewal "A Model for Lentivirus Induced Diseases"
  • Principal Investigator: Tom R. Phillips
  • Project Period: 09/01/99 - 08/30/04
  • Direct Yearly Costs: $196,562
  • Total Direct Costs: $834,693

6. NIH: Program Project: "Methamphetamine and AIDS: Toxic Interactions in Animals"
  • Scientific Director: Steven Henriksen
  • Principal Investigator - Research Component Project #2, Tom R. Phillips
  • Project Period: 04/01/00 - 03/31/05
  • Project Direct Yearly Costs (Component): $150,982
  • Total Direct Costs (Component): $754,910

Particle

Chart

PUBLICATIONS:

  1. Phillips, T.R., W.C. Yang, and R.D. Schultz. The Effects of Glucocorticosteroids on the Chemiluminescence Response of Bovine Phagocytic Cells. Vet Immunol Immunopathol. 14(3):245-256, 1987.
  2. Phillips, T.R., Yang, W.C., Schultz, R.D. In vitro Effects of Prostaglandin E1, Prostaglandin E2, Indomethacin, Histamine, and Tuftsin on the Chemiluminescence Response of Bovine Polymorphonuclear Leukocytes. Vet Immunol Immunopathol. 14(3):233-244, 1987.
  3. Phillips, T.R. and R.D. Schultz. Failure of Vaccine or Virulent Strains of Canine Parvovirus to Induce Immunosuppressive Effects on the Immune System of the Dog. Viral Immunol. 1(2):135-144, 1987.
  4. Czuprynski, C.J., C.B. Thomas, W.C. Yang, T.R. Phillips, L. Kaufman, and R.D. Schultz. Epidemiological and Immunological Evaluation of an Outbreak of Canine Blastomycosis. Journal of Medical and Veterinary Mycology 26:243-252, 1988.
  5. Phillips, T.R., J.L. Jensen, M.J. Rubino, W.C. Yang, and R.D. Schultz. Effects of Vaccines on the Canine Immune System. Can J Vet Res 3:154-160, 1989.
  6. Phillips, T.R., R.L. Talbott, C. Lamont, S. Muir, K. Lovelace, and J.H. Elder. Comparison of two host cell range variants of feline immunodeficiency virus. J Virol 64(10):4605-4613, 1990
  7. Lamont, C., P. Culp, R.L. Talbott, T.R. Phillips, R.J. Trauger, W.N. Frankel, M.C. Wilson, J.M. Coffin, and J.H. Elder. Characterization of endogenous and recombinant proviral elements of a highly tumorigenic AKR cell line. J Virol 65:4619-4628, 1991.
  8. Elder, J.H., D.L. Lerner, C.S. Hasselkus-Light, D.J. Fontenot, E. Hunter, P.A. Luciw, R.C. Montelaro and T.R. Phillips. Distinct subsets of retroviruses encode dUTPase. J. Virol. 66:1791-1794, 1992.
  9. Dandekar, S., A.M. Beebe, J. Barlough, T. Phillips, J. Elder, M. Torten, and N. Pedersen. Detection of feline immunodeficiency virus (FIV) nucleic acids in FIV-seronegative cats. J Virol. 66:4040-4049, 1992.
  10. Phillips, T.R., C. Lamont, D.A.M. Konings, B.L. Shacklett, C.A. Hamson, P.A. Luciw, and J.H. Elder. Identification of the REV transactivation and REV responsive element of feline immunodeficiency virus. J Virol. 66:5464-5471, 1992. Phillips, T.R. and R.D. Schultz. Canine and Feline Vaccines. In: Kirk s Current Veterinary Therapy XI, Kirk, R.W. and Bonagura, J.D. (eds), W.B. Saunders Company, Philadelphia, 202-207, 1992.
  11. Phillips, T.R. Canine Immune System. In: Encyclopedia of Immunology, Roitt, I.M. and Delves, P.J. (eds.) Academic Press Limited, London, England. 1:275-277, 1992.
  12. Elder, J.H., M. Schnolser, C.S. Hasselkus-Light, M. Henson, D.A. Lerner, T.R. Phillips, P.C. Wagaman, and S.B.H. Kent. Identification of Proteolytic Processing Sites within the Gag and Pol polyproteins of Feline Immunodeficiency Virus. J Virol 67:1869-1876, 1993.
  13. Wagaman, P. C., C.S. Hasselkus-Light, M. Henson, D.L. Lerner, T.R. Phillips, and J.H. Elder. Molecular cloning and characterization of deoxyuridine triphosphatase from feline immunodeficiency virus (FIV). Virology. 196:451-457, 1993.
  14. Remington, K.M., Y.Q. Zhu, T.R. Phillips, and T.W. North. Rapid Phenotypic Reversion of Zidovudine-Resistant Feline Immunodeficiency Virus Without Loss of Drug-Resistant Reverse Transcriptase. J Virol 68(2): 632-637, 1994.
  15. Mancuso, F.A., T.J.Hope, L. Zhu, D. Derse, T.R. Phillips, and T.G. Parslow. Post-Transcriptional Effector Domains in the Rev Proteins of Feline Immunodeficiency Virus and Equine Infectious Anemia Virus. J Virol 68(3):1998-2001, 1994.
  16. Elder, J.H., and T.R. Phillips. Molecular Properties of Feline Immunodeficiency Virus (FIV). Infectious Agents and Disease 2:361-374, 1994.
  17. Prospero-Garcia, O., N. Herold, A.K. Waters, T.R. Phillips, J.H. Elder, and S.J. Henriksen. Intraventricular Administration of a FIV-Envelope Protein Induces Sleep Architecture Changes in Rats. Brain Research. 254-258, 1994.
  18. Phillips, T.R., O. Prospero-Garcia, D.L. Puaoi, D.L. Lerner, H.S. Fox, R.A. Olmsted, F.E. Bloom, S.J. Henriksen, and J.H. Elder. Neurological abnormalities associated with feline immunodeficiency virus infection. J Gen Virol. 75:979-987, 1994.
  19. Prospero-Garcia,O, N. Herold, T.R. Phillips, J.H. Elder, F.E. Bloom, and S.J. Henriksen. Sleep Patterns are Disturbed in Cats Infected with Feline Immunodeficiency Virus. Proc. Natl. Acad. Sci. 91:12947-12951, 1994.
  20. Lerner, D.L., P.C. Wagaman, T.R. Phillips, O. Prospero-Garcia, S.J. Henriksen, H.S. Fox, F.E. Bloom, and J.H. Elder. Increased Mutation Frequency of FIV Lacking Functional Deoxyuridine Triphosphatase. Proc. Natl. Acad. Sci. U S A, 92:7480-7484, 1995.
  21. Elder, J.H. and T.R. Phillips. The Genomic Organization of FIV. In: Feline Immunology and Immunodeficiency, Chap. X. Willett, B.J., Jarvett, O.(eds.) Oxford Press, United Kingdom. 220-242, 1995.
  22. Henriksen, S.J., O. Prospero-Garcia, T.R. Phillips, H.S. Fox, F.E. Bloom and J.H. Elder. FIV as a Model for Study of Lentivirus Infection of the CNS. In: Current Topics in Microbiology and Immunology, Volume on HIV and Dementia. Oldstone and Vitkovic (eds). Springer-Verlag. Heidelberg. 202:167-186, 1995.
  23. Henriksen, S., Prospero-Garcia, O., Phillips, T., Fox, H., Bloom, F., Elder, J. FIV as a model for study of lentivirus-induced CNS disease. In: Proc.: Animal Models Recapitulate Aspects of the HIV/CNS Disease. L. Vitkovic, E. Stover and S. Koslow, AIDS Research and Human Retroviruses. 11(6):753-59, 1995.
  24. Elder, J.H. and T.R. Phillips. Feline Immunodeficiency Virus (FIV) as a Model for Development of Molecular Approaches to Intervention Strategies Against Lentivirus Infections. In: Advances In Virus Research. K. Matamorosch, F. Murphy, and A. Shatkin (eds). Academic Press, Florida. 45:225-247, 1995.
  25. Medlin, H.K., Zhu, Y.Q., Remington, K.M., Phillips, T.R., and North, T.W. Selection and Characterization of a Mutant of Feline Immunodeficiency Virus Resistant to 2 ,3 -dideoxycytidine. Antimicrob. Agents Chemother. 40:953-957, 1996.
  26. Phillips, T.R., O. Prospero-Garcia, D.W. Wheeler, P.C. Wagaman, D.L. Lerner, H.S. Fox, L.R. Whalen, F.E. Bloom, J.H. Elder, and S.J. Henriksen. Neurologic Dysfunctions Caused by a Molecular Clone of Feline Immunodeficiency Virus, FIV-PPR. J. NeuroVirol. 2:388-396, 1996.
  27. Jacobson, S., Henriksen, S.J., Prospero-Garcia, O., Phillips, T.R., Elder, J.H., Young, WG., Bloom, F.E., and Fox, H.S. Cortical Neuronal Cytoskeletal Changes Associated with FIV-Infection. J. NeuroVirol.. 3:283-289, 1997.
  28. Billaud, Jean-Noel, Tom R. Phillips. FIV: A Lentivirus Model for Opiate Effects on Disease. Adv. Exp. Med. Biol. 437:101-16, 1998.
  29. Yu, N., J.N. Billaud, T.R. Phillips. Effects of feline immunodeficiency virus on astrocyte glutamate uptake: Implications for lentivirus-induced central nervous system diseases. Proc. Natl. Acad. Sci. U S A. 95:2624-2629, 1998.
  30. Gruol, D.L., N. Yu, K.L. Parsons, J.N. Billaud, J.H. Elder, T.R. Phillips. Neurotoxic Effects of Feline Immunodeficiency Virus, FIV-PPR. J. NeuroVirol . 4:415-425, 1998.
  31. Phillips, T.R. Canine Immune System. In: Encyclopedia of Immunology Second Edition, Roitt, I.M. and Delves, P.J. (eds.) Adademic Press Limited, London, England 1:411-414, 1998.
  32. Prospero-Garcia O, Huitron-Resendiz S, Casalman SC, Sanchez-Alavez M, Diaz-Ruiz O, Navarro L, Lerner DL, Phillips TR, Elder JH, Henriksen SJ. Feline immunodeficiency virus envelope protein (FIVgp120) causes electrophysiological alterations in rats. Brain Res 31;836(1-2):203-9, 1999.
  33. Barr, M.C., S. Huitron-Resendiz, D. Selway, S. Henriksen, and T.R. Phillips. Exogenous glucocorticoids alter the course of early feline immunodeficiency virus infection. Journal of Infectious Disease:181 576-86, 2000.
  34. J.N. Billaud, D. Selway, N. Yu, and T.R. Phillips. Replication Rate of Feline Immunodeficiency Virus in Astrocytes is Envelope-Dependent: Implications for Glutamate Uptake. Virology: 266:180-188, 2000.
  35. Barr M.C., Billaud J.N., Selway, D., Huitron-Resendiz S., Osborn K.G., Henriksen S.J., Phillips T.R. Effects of Multiple Acute Morphine Exposures on Feline Immunodeficiency Virus (FIV) Disease Progression. Journal of Infectious Disease 182:725-732, 2000
  36. Phillips, T.R., J.N. Billaud, and S. J. Henriksen. Methamphetamine and HIV-1: Potential Interactions and the Use of the FIV/cat Model Psychopharmacological effects of Drug abuse in animal models of AIDS dementia. J Psychopharmacol. 14:244-50, 2000.
  37. Jean-Noel Billaud, Calvin Ly, Tom R. Phillips and Juan Carlos de la Torre. Borna disease virus persistence causes inhibition of glutamate uptake by feline primary cortical astrocytes. J Virol. 74:10438-46, 2000.
  38. O. Billet, J.N. Billaud, and T.R. Phillips. Partial Characterization and tissue distribution of the Feline µ Opiate Receptor. Drug Alcohol Depend. 62:125-129, 2001
  39. Milich D.R, Hugh J., Jones J., Sallberg M., and Phillips T.R. Conversion of poorly immunogenic malaria repeat sequences into a highly immunogenic vaccine candidate. Vaccine 20:771-788. 2001
  40. Fox HS. and TR. Phillips. FIV and neuroAIDS. J Neurovirol. 3:155-7, 2002.
  41. Sharma, S.K., J.N. Billaud, manju Tandon, O. Billet, S. Choi. M.L. Kopka, T.R. Phillips, and J.W. Lown. Inhibition of Feline Immunodeficiency Virus (FIV) Replication by DNA Polyamides. Bioorg. Med. Chem. Lett. 12:2007-10, 2002
  42. Hart R.A., Billaud J.N., Choi SJ, and T.R. Phillips. Inhibition of Rev function in FIV by 1,8 diaminooctane. Virology, 304(1):97-104, 2002
  43. Sallberg M., J. Hughes, J. Jones, T.R.Phillips, and D.R. Milich. A malaria vaccine candidate based on a hepatitis B virus core platform. Intervirology. 2002;45(4-6):350-61
  44. Barr, M.C., S. Huitron-Resendiz, M. Sanchez-Alavez,S.J. Henriksen, and T.R. Phillips. Escalating morphine exposures followed by withdrawal in feline immunodeficiency virus-infected cats: a model for HIV infection in chronic opiate abusers. Drug Alcohol Depend. 2003; 24;72(2):141-9.
  45. Cloak C.C., L. Chang, T. Ernst, M.C. Barr, S. Huitron-Resendiz, M. Sanchez-Alavez, T.R. Phillips, S. Henriksen. Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease. J Neuroimmunol. 2004; 147(1-2):16-20.
  46. Barr MC, MP Testa, and TR Phillips. Drugs of Abuse, AIDS, and the FIV Model. In: In Vivo Models of HIV Disease and Control. Herman Friedman, Steven Specter, Mauro Bendinelli (Editors) 2006
  47. Huitron-Resendiz, S., M.C. Barr, M.P. Testa, C.M. Leutenegger, S.J. Henriksen, and T.R. Phillips. Methamphetamine and lentivirus interactions: Reciprocal enhancement of CNS disease. (Submitted), 2006.

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