Selected Publications (from 2010)
2019
Heysieattalab S, Lee KH, Liu Y, Wang Y, Foy MR, Bi X, Baudry M (2019) Impaired cerebellar plasticity and eye-blink conditioning in calpain-1 knock-out mice. Neurobiol Learn Mem. 2019 Feb 5. pii: S1074-7427(19)30015-2. doi: 10.1016/j.nlm.2019.02.005. [Epub ahead of print] PMID: 30735788
Liu Y., Johe K., Sun J., Hao X., Wang Y., Bi X, Baudry M. (2019) Enhancement of synaptic plasticity and reversal of impairments in motor and cognitive functions in a mouse model of Angelman Syndrome by a small neurogenic molecule, NSI-189. Neuropharmacology. 2019 Jan;144:337-344. doi: 10.1016/j.neuropharm.2018.10.038. Epub 2018 Nov 5.PMID: 3002 0076 (2018) PMID: 30408487
2018
Sun J, Liu Y, Jia Y, Hao X, Lin WJ, Tran J, Lynch G, Baudry M, Bi X (2018). UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. Elife. 2018 Jul 18;7. pii: e37993. doi: 10.7554/eLife.37993. [Epub ahead of print] PMID: 30020076
Wang, Y., Bi, X., and Baudry M (2018) Calpain-2 as a therapeutic target for acute neuronal injury. Expert Opin Ther Targets. 2018 Jan;22(1):19-29. doi: 10.1080/14728222.2018.1409723. Epub 2017 Nov 28. Review. PMID: 29168923 PMID: 29168923
2017
Wang, Y., Hall R.A., Lee, M., Kamgar-Parsi, A., Bi, X., and Baudry M (2017) The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation. Sci Rep. 2017 Sep 18;7(1):11771. doi: 10.1038/s41598-017-12236-3. PMID: 28924170
Wang, Y., Liu Y., Lopez D., Lee M., Dayal S., Hurtado A., Bi, X., and Baudry M (2017) Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice. J Neurotrauma. 2017 Jun 8. doi: 10.1089/neu.2017.5024. [Epub ahead of print] PMID: 28594313
Zhu G., Briz V., Seinfeld J., Liu Y., Bi X., Baudry M. (2017) Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction. Sci. Rep 2017 Feb 16;7:42788. doi: 10.1038/srep42788. PMID: 28202907
Sun J, Baudry M, Bi X. (2017) Novel neurobiological roles of UBE3A. Oncotarget. 2017 Feb 5. doi: 10.18632/oncotarget.15105. [Epub ahead of print] PMID: 28179584
2016
Seinfeld J, Baudry N, Xu X., Bi X., and Baudry M (2016) Differential activation of calpain-1 and calpain-2 following kainate-induced seizure activity in rats and mice. eNeuro 2016; 10.1523/ENEURO.0088-15.2016 PMID: 27622212
Liu Y., Sun J., Wang Y., Lopez D., Tran J., Bi X, Baudry M. (2016) Deleting both PHLPP1 and CANP1 rescues impairments in long-term potentiation and learning in both single knockout mice. Learn Mem. 2016 Jul 15;23(8):399-404. doi: 10.1101/lm.042721.116. Print 2016 Aug. PMID: 27421891
Wang, Y., Lopez D., Davey P.G., Cameron J., Nguyen K., Tran J., Marquez E., Liu Y., Bi, X., and Baudry M (2016) Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury. Neurobiol Dis. 2016 Sep;93:121-8. doi: 10.1016/j.nbd.2016.05.007. Epub 2016 May 13. PMID: 27185592
Wang Y, Hersheson J, Lopez D, Hammer M, Liu Y, Lee KH, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, Coutelier M, Brice A, Stevanin G, Durr A, Bi X, Houlden H, Baudry M. (2016) Defects in the CAPN1 gene result in alterations in cerebellar development and in cerebellar ataxia in mice and humans. Cell Rep. 2016 Jun 28;16(1):79-91. doi: 10.1016/j.celrep.2016.05.044. Epub 2016 Jun 16. PMID: 27320912.
Sun J., Liu Y., Tran J., O’Neal P., Baudry M., and Bi X. (2016) mTORC1-S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice. Cell Mol Life Sci. 2016 Nov;73(22):4303-4314. PMID: 27173058
Liu Y, Wang Y., Zhu G, Sun J., Bi X, Baudry M. (2016) A calpain-2 selective inhibitor enhances learning & memory by prolonging ERK activation. Neuropharm. Feb 18;105:471-477. doi: 10.1016/j.neuropharm.2016.02.022. [Epub ahead of print] PMID: 26907807
Baudry M., and Bi X. (2016) Calpain-1 and calpain-2: The yin and yang of synaptic plasticity and neurodegeneration. Trend Neurosci. 39(4):235-45. doi: 10.1016/j.tins.2016.01.007. Epub 2016 PMID: 26874794
Bi, X. Sun, J, Ji, A.X. Baudry, M (2016) Potential therapeutic approaches for Angelman syndrome. Expert Opin Ther Targets. 2016 2016;20(5):601-13. doi: 10.1517/14728222.2016.1115837. PMID: 26558806
2015
Briz V, Liu Y, Zhu G, Bi X, Baudry M. (2015) A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J Cell Biol 2015 Sep 28;210(7):1225-37. doi: 10.1083/jcb.201504092. Epub 2015 Sep 21. PMID: 26391661
Sun J, Liu Y, Zhu G., Standley S., Ji A., Tunuguntla R., Wang Y., Claus C., Lou Y., Baudry M., Bi X. (2015) UBE3A regulates synaptic plasticity and learning and memory by controlling SK2 channel endocytosis. Cell Rep. 2015 Jul 21;12(3):449-61. doi: 10.1016/j.celrep.2015.06.023. Epub 2015 Jul 9. PMID: 26166566
Bi, X. Sun, J, and Baudry, M (2015) Yin-and-Yang of mTORC1/C2 in Angelman syndrome. Oncotarget, Vol. 6, No. 16. 13844-13845. Editorial. PMID: 26116835
Liao G., Wang Z., Lee E., Moreno S., Abuelnasr O., Baudry M., Bi X (2015) Enhanced expression of matrix metalloproteinase-12 contributes to Npc1 deficiency-induced axonal degeneration. Exp Neurol 269:67-74. PMID: 25864931
Sun J, Liu Y, Moreno S., Baudry M, Bi X (2015) Imbalanced mTORC1 and mTORC2 activity in cerebellum of Angelman syndrome mice impairs motor function. J Neurosci 35(11): 4706-4718. PMID: 25788687
Briz V, Zhu G, Wang Y, Liu Y, Avetisyam M, Bi X, Baudry M. (2015) Activity-dependent rapid local RhoA synthesis is required for hippocampal synaptic plasticity. J Neurosci ;35(5):2269-2282. PMID: 25653381
Zhu G, Liu Y, Wang Y, Bi X, Baudry M. (2015) Different Patterns of Electrical Activity Lead to Long-term Potentiation by Activating Different Intracellular Pathways. J Neurosci ;35(2):621-33. PMID: 25589756
Baudry M, Zhu G, Liu Y, Wang Y, Briz V, Bi X. (2015) Multiple cellular cascades participate in long-term potentiation and in hippocampus-dependent learning. Brain Res. 2015 Sep 24;1621:73-81. doi: 10.1016/j.brainres.2014.11.033. Epub 2014 Dec 4. PMID: 25482663
2014
Wang, Y., Zhu, G., Briz, V., Hsu, Y.-T., Bi, X., and Baudry M, (2014) A molecular brake controls the magnitude of long-term potentiation. Nature Commun 2014;5:3051. doi: 10.1038/ncomms4051. PMID: 24394804
2013
Wang, Y., Briz V., Chishti A., Bi X., Baudry M. (2013) Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 2013 Nov 27;33(48):18880-92. doi: 10.1523/JNEUROSCI.3293-13.2013. PMID: 24285894
Baudry, M., Bi, X. (2013) Learning and memory: An emergent property of cell motility. Neurobiol Learn Mem. 2013 May 21;104C:64-72. PMID: 23707799
Briz, V., Hsu, Y.-T., Li, Y., Lee, E., Bi, X., and Baudry, M (2013) Calpain-2-mediated PTEN degradation contributes to BDNF-induced stimulation of dendritic protein synthesis. J. Neurosci. 2013 Mar 6;33(10):4317-28. PMID: 23467348
Baudry, M., Chou, M.M., and Bi, X. (2013) Targeting calpain in synaptic plasticity. Expert Opin Ther Targets. 2013 May;17(5):579-92. PMID: 23379852
Baudry, M., Bi, X., and Aguirr, C. (2012) Progesterone-estrogen interactions in synaptic plasticity and neuroprotection. Neuroscience. 2013 Jun 3;239:280-94. 2012 Nov 7. PMID: 23142339
2012
Allyson, J., Bi, X., Baudry, M., and Massicotte G. (2012) Maintenance of synaptic stability requires calcium-independent phospholipase A2 activity. Neural Plasticity. 2012:569149. doi: 10.1155/2012/569149. Epub 2012 May 20. PMID: 22685677
Baudry, M., Kramar, E., Xu, X., Zadran, H., Moreno, S., Lynch, G., Gall C., and Bi, X. (2012) Ampakines promote spine actin polymerization, long-term potentiation, and learning in a mouse model of Angelman Syndrome. Neurobiol. Dis. 47(2):210-5. Epub 2012 Apr 16. PMID: 22525571
Clausen A., Xu X., Bi X., and Baudry M. (2012) Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s disease: Protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J Alzheimers Dis. 30(1):183-208. PMID: 22406441
2011
Hsu Y.-T., Liao G., Bi X., Oka, T., Tamura, S., and Baudry, M. (2011) The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices. Neuropharmacology. 2011 Dec;61(8):1275-81. Epub 2011 Jul 28. PMID: 21816164
Yu L., Rostamiani K., Hsu Y.-T., Wang Y., Bi X., and Baudry M. (2011) Calpain-mediated regulation of stargazin in adult rat brain. Neuroscience 2011 Mar 31;178:13-20. Epub 2011 Jan 20. PMID: 21256931
Baudry M., Bi X., Gall C.M., and Lynch G. (2011) The Biochemistry of Memory: The Twenty-Six Year Journey of a ‘New and Specific Hypothesis’ Neurobiol Learn Mem. 2011 Feb;95(2):125-33. Epub 2010 Dec 4. PMID: 21134478
2010
Zadran S., Bi X. and Baudry, M. (2010) Regulation of calpain-2 in neurons: Implications for synaptic plasticity. Mol. Neurobiol. 2010 Oct;42(2):143-150. Epub 2010 Oct 6. PMID: 20924799
Qin, Q., Liao, G., Baudry, M., and Bi X. (2010) Role of calpain-mediated p53 truncation in semaphorin 3A-induced axonal growth regulation. Proc. Nat. Acad. Sci. USA 107(31):13883-7. Epub 2010 Jul 19. PMID: 20643936
Qin Q., Liao, G., Baudry M., and Bi X. (2010) Cholesterol perturbation in mice results in p53 degradation and axonal pathology through p38 MAPK and Mdm2 activation. PLoS ONE 5(4): e9999. doi:10.1371/journal.pone.0009999 PMID: 20386595
Zadran S., Jourdi H., Rostamiani K., Qin Q., Bi X. and Baudry, M. (2010) BDNF- and EGF-mediated neuronal calpain activation through MAPK-dependent phosphorylation. J. Neurosci, 2010 30: 1086-1095 PMID: 20089917
Liao, G., Wen, Z., Irizarry, K., Huang, Y., Mitsouras, K., Darmani, M., Leon, T., Shi, L. and Bi, X. (2010). Abnormal gene expression in cerebellum of Npc1-/- mice during postnatal development. Brain Res. 1325:128-140 PMID: 20153740
Bi X, Liao G. (2010) Cholesterol in Niemann-Pick Type C disease. Subcell Biochem. 2010;51:319-35. doi: 10.1007/978-90-481-8622-8_11. Review. PMID: 20213549