College of Osteopathic Medicine of the Pacific


• Chang R, Hernandez J, Gastelum C, Guadagno K, Perez L, Wagner E, J: Pituitary Adenylate Cyclase-Activating Polypeptide Excites Proopiomelanocortin Neurons: Implications for the Regulation of Energy Homeostasis. Neuroendocrinology 2020. doi: 10.1159/000506367

• Hernandez J, Fabelo C, Perez L, Moore C, Chang R, Wagner EJ. Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner. Biol Sex Differ. 2019;10(1):9. Published 2019 Feb 12. doi:10.1186/s13293-019-0220-3

• Fabelo C, Hernandez J, Chang R, et al. Endocannabinoid Signaling at Hypothalamic Steroidogenic Factor-1/Proopiomelanocortin Synapses Is Sex- and Diet-Sensitive. Front Mol Neurosci. 2018;11:214. Published 2018 Jun 19. doi:10.3389/fnmol.2018.00214

• Qiu J. Bosch MA, Meza C, Navarro U, Nestor CC, Wagner EJ, Rønnekleiv OK and Kelly MJ. Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance. Endocrinology. February 2018, 159(2):647-664.

• Qiu J, Wagner EJ, Rønnekleiv OK, Kelly MJ. Insulin and Leptin Excite Anorexigenic Pro-Opiomelanocortin Neurones via Activation of TRPC5 Channels. Journal of Neuroendocrionolgy. June 2017. DOI: 10.1111/jne.12501.

• Conde K, Fabelo C, Krause WC, Propst R, Goethel J, Fischer D, Hur J, Meza C, Ingraham HA, Wagner EJ. Testosterone Rapidly Augments Retrograde Endocannabinoid Signaling in Proopiomelanocortin Neurons to Suppress Glutamatergic Input from Steroidogenic Factor-1 Neurons via Upregulation of Diacylglycerol Lipase-a. Neuroendocrinology. 2016 Nov. 21 PMID:27871072

• Wagner EJ. Sex differences in cannabinoid-regulated biology: A focus on energy homeostasis. Front Neuroendocrinol. 2016 Jan;40:101-9. doi 10.1016/j.yfrbe.2106.01.003. Epub 2016 Jan 19.

• Conde K, Meza C, Kelly MJ, Sinchak K, Wagner EJ. Estradiol Rapidly Attenuates ORL-1 Receptor-Mediated Inhibition of Proopiomelanocortin Neurons via Gq-Coupled, Membrane-Initiated Signaling. Neuroendocrinology. 2016 Jan 16. PMID:26765570

• Mela V, Vargas A, Meza C, Kachani M, Wagner EJ. Modulatory influences of estradiol and other anorexigenic hormones on metabotropic:Gi/O-coupled receptor function in the hypothalamic control of energy homeostasis. J Steroid Biochem Mol Biol. 2015 Jul 28. pii: S0960-0760(15)30027-3. doi:10.1016/j.jsbmb.2015.07.014.

• Borgquist A, Meza C, Wagner EJ. Role of neuronal nitric oxide synthase in the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis. J Neurophysiol. 2015 Feb 1;113(3):904-14. doi: 10.1152/jn.00615.2014. Epub 2014 Nov 12.

• Borgquist A, Meza C, Wagner EJ. The role of AMP-activated protein kinase (AMPK) in the androgenic potentiation of cannabinoid-induced changes in energy homeostasis. Am J Physiol Endocrinol Metab. 2014 Dec 30:ajpendo.00421.2014. doi: 10.1152/ajpendo.00421.2014. http://www.ncbi.nlm.nih.gov/pubmed/25550281

• Qiu J, Zhang C, Borgquist A, Nestor CC, Smith AW, Bosch MA, Ku S, Wagner EJ, Rønnekleiv OK, Kelly MJ. Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels. Cell Metab. 2014 Apr 1;19(4):682-93. doi: 10.1016/j.cmet.2014.03.004.

• Borgquist A, Kachani M, Tavitian N, Sinchak K, Wagner EJ. Estradiol negatively modulates the pleiotropic actions of orphanin FQ/nociceptin at proopiomelanocortin synapses. Neuroendocrinology. 2013;98(1):60-72. doi: 10.1159/000351868. Epub 2013 Jul 2.

• Sinchak K, Wagner EJ. Estradiol signaling in the regulation of reproduction and energy balance. Front Neuroendocrinol. 2012 Oct;33(4):342-63. doi: 10.1016/j.yfrne.2012.08.004. Epub 2012 Sep 7.

• Viveros MP, Mendrek A, Paus T, Lopez-Rodriguez AB, Marco EM, Yehuda R, Cohen H, Lehrner A, Wagner EJ: A comparative, developmental, and clinical perspective of neurobehavioral sexual dimorphisms. Frontiers in Neuroscience 2012 Jun 12;6:84. doi: 10.3389/fnins.2012.00084.

• Washburn N, Borgquist A, Wang K, Jeffery GS, Kelly MJ, Wagner EJ: Receptor subtypes and signal transduction mechanisms contributing to the estrogenic attenuation of cannabinoid-induced changes in energy homeostasis. Neuroendocrinology 2013;97(2):160-75. doi: 10.1159/000338669.

• Viveros MP, Bermudez-Silva FJ, Lopez-Rodriguez AB and Wagner EJ. The Endocannabinoid System as Pharmacological Target Derived from Its CNS Role in Energy Homeostasis and Reward. Applications in Eating Disorders and Addiction. Pharmaceuticals 2011, 4(8), 1101-1136; doi:10.3390/ph4081101.

• Viveros MP, Marco E, Lopez-Gallardo M, Garcia-Segura LM and Wagner EJ. Framework for sex differences in adolescent neurobiology: A focus on cannabinoids. Neuroscience and Biobehavioral Reviews 2011, 35 (8), pp. 1740-1751.

• Jeffery GS, Peng KC and Wagner EJ. The role of phosphatidylinositol-3-kinase and AMP-activated kinase in the rapid estrogenic attenuation of cannabinoid-induced changes in energy homeostasis. Pharmaceuticals 2011, 4 (4), pp. 630-651.