Gerald Thrush, PhD
Associate Dean of Academic Affairs
Professor of Immunology
College of Osteopathic Medicine of the Pacific
Join year: 2006
Ph.D., Immunology/Microbiology, Wayne State University, Detroit, MI, 1990 B.S., Biology, Saginaw Valley State University Saginaw, MI, 1985.
Professor, Department of Basic Medical Sciences, COMP/Western University of Health Sciences, 2006-present Associate Professor, Department of Biology, California State University San Bernardino. 2000-2006 Associate Dean, College of Natural Sciences, California State University, San Bernardino. 2000-2003 Assistant Professor, Department of Biology, California State University, San Bernardino. 1996-2000 Instructor, Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX. 1993-1996 Assistant Instructor, Cancer Immunobiology Center, University of Texas Southwestern Medical Center, Dallas, TX, 1991-1993
Immunology lectures, IDIT module, OMSI Blood & Lymphatics system, OMSI; Course director Molecular and Cellular Basis of Life lectures; MSMS program, GCBS Microbiology lectures, MSMS program, GCBS; Course director
Therapy of lymphomas with immunotoxins comprised of soluble T-cell receptors conjugated to ricin A-chain.
Immunotoxins are conjugates of cell-binding moieties linked to toxins or toxin subunits. Many investigators have used antibodies directed against tumor specific-antigens as the cell- binding moiety. B-cell tumors are ideal for this type of therapy because of their tumor-specific idiotype (Id). However, B-cell tumors often secrete Id which competes with tumor cells for binding of anti-Id antibodies. Therefore, to overcome this obstacle, my research focuses on developing soluble T-cell receptors (TCR) from tumor specific T cell clones as the cell-binding moiety, and ricin-A chain as the toxic moiety. T-cells recognize cell-bound (but not soluble) antigen in association with products of the major histocompatibility complex. Therefore, free idiotype should not interfere with binding of soluble TCRs to tumor cells. Id specific T-cells have been cloned from mice immunized with the murine tumor, BCL1. The TCR genes from these BCL-specific T cells have been cloned and attempts are underway to express a soluble form of these molecules. Once successful, ricin A-chain will be linked to the soluble TCRs biochemically or genetically. These conjugates will then be used to kill BCL1 tumor cells in vitro and in vivo.
Incidence of Lyme disease bacteria in San Bernardino, CA
A new research direction within my lab involves determining the incidence of the bacterium, Borrelia burghdorferi in the local area. This organism is the causative agent in Lyme disease in humans and animals. The bacteria is transmitted via the bite of ticks (Ixodes pacificus in California ). This organism has been readily found in northern California and cases of Lyme disease has also been reported. While there have been causes of Lyme disease in southern California , the incidence is low. In addition, an extensive survey of the local area has not been completed. In order to determine whether the organism is in our local tick population, the polymerase chain technique will be used to identify the bacteria.
- Western U intramural research grant ($15,000) 2007-2008
- CSUSB Faculty Professional Study awards ($6,369) 1997-2005
- CSUSB Faculty Professional Development grants ($24,153) 1996-2005
- AREA grant (R15), National Cancer Institute ($95,000) 1999-2002
- CSUSB Junior faculty Professional Development grant ($5,595) 1997-1998
- American Cancer Society Fellowship ($78,000) 1992-1995
- Distinguished Faculty Award for Teaching and Education, 2015-2-16
- Poster presentation, certificate of merit, Asia Pacific Medical Education Conference (APMEC), Singapore, Singapore, 2015
- Outstanding Basic Science faculty (voted by DO 2018 Lebanon), 2015
- Outstanding Basic Science faculty (voted by DO 2016 Pomona), 2014
- Outstanding Basic Science faculty (voted by DO 2017 Lebanon), 2014
- Lifelong Learning: Teaching Innovation (voted by the faculty), 2014
- Outstanding Basic Science Faculty (voted by the OMSI students), 2013
- Lifelong Learning: Teaching Innovation (voted by the faculty), 2013
- Outstanding Basic Science Faculty (voted by the OMSI and OMSII students), 2012
- Outstanding Faculty Award – Student focus (voted by the faculty), 2012
- Outstanding Faculty Award – Teamwork (voted by the faculty), 2011
- Outstanding Faculty Award – Lifelong learning; teaching innovation (voted by the faculty), 2011
- Outstanding Faculty Award – Student Focus (voted by the faculty), 2011
- Outstanding Basic Science Faculty Award (voted by the OMSI and OMSII students), 2011
- Golden Antibody Award, Basic Medical Sciences, COMP/Western University, (voted by OMSI students), 2009
- Outstanding Basic Sciences Professor of the Year, Basic Medical Sciences, (voted by OMSII students), 2008
- Outstanding Basic Sciences Professor of the Year, Basic Medical Sciences, (voted by OMSII students), 2007
- CSUSB Golden Apple winter ("Teacher of the Year" award), 2005
- College of Natural Sciences Award for Outstanding Teaching-related activities, 2004-2005
- College of Natural Sciences Award for Outstanding Service to the College, 2002-2003
- Outstanding Faculty Advisor of the Year, 2000
- CSUSB Student Organization Advisor of the Year, 1998-1999
American Association of Immunologists American Society for Microbiology
- Hubbard S, Darmani NA, Thrush GR, Dey D, Burnham L, Thompson JM, Jones K and Tiwari V. Zebrafish-encoded 3-O-sulfotransferase-3 isoform mediates herpes simplex virus type 1 entry and spread. Zebrafish. 2010 Jun;7(2):181-7.
- Tiwari V, Darmani NA, Thrush GR and Shukla D. An unusual dependence of human herpesvirus-8 glycoproteins-induced cell-to-cell fusion on heparan sulfate. Biochem Biophys Res Commun. 2009 Dec 18;390(3):382-7.
- Darmani NA, Wang Y, Abad J, Ray AP, Thrush GR and Ramirez J. Utilization of the least shrew as a rapid and selective screening model for the antiemetic potential and brain penetration of substance P and NK1 receptor antagonists. Brain Res. 2008 Jun 12;1214:58-72.
- Farrar JD, Katz KH, Thrush GR, Scheuermann RH, Uhr JW, and Street NE. Cancer dormancy VI: Regulation of the dormant state by CD8+ T cells. Journal of Immunology. 1999;162: 2842-2849.
- Thrush GR, Lark LR, Clinchy BC and Vitetta ES. Immunotoxins: An Update. Annu Rev Immunol. 1996;14:49-71.
- Thrush GR, Lark LR and Vitetta ES. Immunotoxins. Chapter 30, pg. 385-397. IN: Therapeutic Immunology, A Major Reference Text, K.F. Austen, S.J. Burakoff, F.S. Rosen, and T.B. Storm, eds., Blackwell Scientific Publications, Inc., Cambridge, MA, 1996.
- Thrush G, Camberos P and Helf S. (Poster Presentation). Do we truly assess what we teach? Technology powered curriculum gap analysis. Asia Pacific Medical Education Conference (APMEC), Singapore, Singapore. November 9-11, 2015.
- Mackintosh S, Thrush G, Satterfield K and McMahon L. (Poster Presentation). Consistent Application of Learning Outcomes in Assessment. Association of Medical Educators in Europe (AMEE) annual conference. Glasgow, Scotland. September 4-9, 2015.
- Helf S, Ngo N, Camberos P and Thrush G. (Oral Presentation). The Academic Progress Portal: Catching Students Before They Fail. Association of Medical Educators in Europe (AMEE) annual conference. Glasgow, Scotland. September 4-9, 2015
- Camberos P, Helf S, Thrush G and MA T. (Oral Presentation). The Use of Technology to Track Learner Outcomes. Association of Medical Educators in Europe (AMEE) annual conference. Glasgow, Scotland. September 4-9, 2015.
- Helf S, Thrush G, Ma TP. Curriculum Mapping: Flipped, Automated, and Easy. Poster presented at: Educause. September 2014; Orlando, FL.
- Camberos P, Helf S, Thrush G. Real Time Learner Outcome Feedback: Web Mash-ups Made Simple. Poster presented at: International Association of Medical Science Educators; June, 2014; Nashville, TN.
- Helf S, Thrush G and Curran M. Leaving the LMS: Checking out of the Hotel California. Campus Technology 2012, Boston, MA
- Burnham LA, Thrush GR, Chan JK, Thompson J, Tiwari V. Enhanced infection of herpes simplex virus type-1 (HSV-1) into target cells via cationic liposomes. Abstract #ST-1936. 110th General Meeting, San Diego, CA, 2010.
- Roser M and Thrush GR. The identification of three different endosymbionts within a Southern California Population of Dermancentor occidentalis. Abstract #I-036. American Society for Microbiology. 104th General Meeting, New Orleans, LA, 2004.
- Burnham L and Thrush GR. PCR detection of Bartonella spp. in questing adult Ixodes pacificus ticks in California. Abstract #Y-042. American Society for Microbiology, 104th General Meeting, New Orleans, LA, 2004.
- Roser MA and Thrush GR. Identification of three different bacterial endosymbionts in Ixodes pacificus samples taken from San Bernardino County, California. Abstract #I-021. American Society for Microbiology. 103rd General Meeting. Washington, D.C. 2003.
- Allen R and Thrush GR. Distributions of ticks along selected regions of the Pacific Crest Trail and adjacent areas in San Bernardino County, California. 100th General Meeting of the American Society for Microbiology, Los Angeles, CA. Abstract #C-114., pg. 154.
Invited Seminars and Presentations (selected)
- Helf S, Thrush G, Ma TP. Technology to Track Learner Outcomes. Presented at: Osteopathic Medical Education Leadership Conference, American Osteopathic Association; January, 2014; Austin, TX.
- Helf S, Thrush G, Ma TP. Organic Curriculum Mapping: Virtually There, Grounded in Reality. Western Association of Schools and Colleges (WASC), Academic Resource Conference; April 2014; Los Angeles, CA.
- Helf S, Thrush G, Ma TP. Grounded in Reality: Technology Enabled Real Time Curriculum Mapping and Analysis. Campus Technology Forum; Aril 2014; Long Beach, CA.
- Mackintosh S, Thrush G, Helf S, Junkins E. Predicting Success in Medical 2014 School Employing an Innovative Curriculum Delivery Method: A Tale of Two Campuses. American Association of Colleges of Osteopathic Medicine, Annual Conference; April 2014; Washington, DC.
- Helf S, Thrush G, Ma TP. Keynote. Learner Outcomes: Automated Tracking Easy Analysis, and Continuous Curriculum Improvement. Osteopathic European Academic Network Annual Conference; May 2014; Barcelona, Spain.
- Helf S, Thrush G, Ma TP. Automated Curriculum Mapping. Keynote. Osteopathic European Academic Network Annual Conference; June 2014; Barcelona, Spain.
- Helf, S., Ma, T. and G.R. Thrush. June 2014. Learner Outcomes: Automated Tracking, Easy Analysis, and Continuous Curriculum Improvement. Osteopathic Education Annual Conference. Barcelona, Spain.
- Thrush, G. R. and Camberos, P. Real-time learner outcomes feedback: Web mash-ups made simple. CAIR 2013, Napa, CA. November 2013.
- Helf, S., Ma, T., and Thrush, G. (2013). Supporting Students: Academic Planning, Progress, and Learning Analytics. Educause, West/Southwest Regional Conference. Austin, TX.
- Helf S, Ma T, and Thrush G. Thought before action: The theoretical basis for technology to track learner outcomes. AACOM annual convention. Baltimore, MD., April, 2013.