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Jerome Lacroix, PhD

Assistant Professor of Biomedical Sciences

Graduate College of Biomedical Sciences

E-Mail: jlacroix@westernu.edu

Phone: 8201

Website: https://jlacroix9.wixsite.com/thelacroixlaboratory

Join year: 2016

Education

• 2006 PhD, Cell and Molecular Biology, University of Nice-Sophia Antipolis • 2002 Master of Science, Cell and Molecular Pharmacology and Biology, University of Nice-Sophia Antipolis • 2001 Bachelor of Science with Major in Cell Biology and Physiology, École Normale Supérieure de Lyon • 1999 Undergraduate degree, Major in Life Sciences, University of Nice-Sophia Antipolis

Professional Experience

• Assistant Professor, Western University of Health Sciences, Pomona, CA (since 03/2016) • Visiting scientist, California Institute of Technology, Pasadena, CA (since 2016) • Post-doctoral scholar, California Institute of Technology, Pasadena, CA (2014-2016) • Research professional associate, University of Chicago (2011-2013) • Post-doctoral scholar, University of Chicago (2006-2011)

Courses

  • MSMS 5041 Membrane Structure, Transport and Functions
  • MSBS 5060 Biotechnology
  • MSBS 5080 Pathology in human and animal models I
  • MSBS 5081 Pathology in human and animal models II

Research Interest

The Lacroix Laboratory is dedicated to elucidate the gating mechanisms of mechanosensitive ion channels that enable our cells to feel various forms of mechanical forces. We use protein engineering, patch-clamp electrophysiology, fluorescence spectroscopy and non-invasive acoustic stimulations to discover fundamental principles underlying molecular mechanotransduction produced upon mechanical or chemical stimuli. We also create biotechnology that will allow us to "see" mechanical forces acting on cells or to remotely stimulate neurons using focused ultrasound.

Research Grant

R21 NS101384-01A1 "Biophysical Studies of Non-Invasive Brain Cell Stimulation with Focused Ultrasound" - 01/01/2018-12/31/2019 (Principal Investigator)

Awards

• National Merit Scholarship from the French Ministry of National Education and Research (2002-2005) • PhD Fellowship from the Association against Cancer (2005-2006)

Organizations

  • Faculty of F1000 (since 2013)
  • The Biophysical Society (since 2007)

Committees

  • GCBS Research Representative
  • GCBS Faculty Handbook Committee
  • GCBS Academic Technology Representative
  • GCBS Research Representative
  • GCBS Tenure-track Faculty Search Committee
  • GCBS Assessement Committee
  • MSMS Curriculum Committee
  • MSBS Admission Committee

Publications

•Labro A.J., Priest M.F., Lacroix J.J., Snyders D.J., Bezanilla F. (2015) Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization. Nature Communications 6, 10173.

•Kubota, T., Lacroix, J.J, Bezanilla, F. and Correa A.M. (2014) Probing α-310 Transitions in a Voltage-Sensing S4 Helix. Biophysical Journal 107, 1117-1128.

•Lacroix, J.J., Hyde, H. C., Campos, F.V and Bezanilla, F. (2013) Moving Gating Charges through the Gating Pore in a Kv Channel Voltage Sensor. Proc Natl Acad Sci U S A 111, 1950-1959.

•Priest, M. F., Lacroix, J.J., Villalba-Galea C. A. and Bezanilla, F. (2013) S3-S4 Linker length Modulates the Relaxed State of a Voltage-Gated Potassium Channel. Biophysical Journal 105, 2312-22.

•Lacroix, J.J., Campos, F.V, Frezza, L. and Bezanilla, F. (2013) Molecular Bases for the Asynchronous Activation of Sodium and Potassium Channels Required for Nerve Impulses Generation. Neuron 79, 651-57.

•Lacroix, J.J., Pless, S.A., Maragliano, L., Campos, F.V., Galpin, J.D., Ahern, C.A., Roux, B. and Bezanilla, F. (2012) Intermediate State Trapping of a Voltage-Sensor. The Journal of General Physiology 140, 635-52.

•Labro, A.J., Lacroix, J.J., Villalba-Galea, C.A., Snyders, D.J., and Bezanilla, F. (2012) Molecular Mechanism for Depolarization-induced Modulation of Kv Channel Closure. The Journal of General Physiology 140, 481-93.

•Lacroix, J.J. and Bezanilla, F. (2012). Tuning the voltage sensor motion with a single residue. Biophysical Journal 103, 23-25.

•Pang, V., Counillon, L., Lagadic-Gossmann, D., Poet, M., Lacroix, J., Sergent, O., Khan, R., and Rauch, C. (2012). On the role of the difference in surface tensions involved in the allosteric regulation of NHE-1 induced by low to mild osmotic pressure, membrane tension and lipid asymmetry. Cell Biochem Biophys 63, 47-57.

•Allen, M.J., Lacroix, J.J., Ramachandran, S., Capone, R., Whitlock, J.L., Ghadge, G.D., Arnsdorf, M.F., Roos, R.P., and Lal, R. (2012). Mutant SOD1 forms ion channel: implications for ALS pathophysiology. Neurobiology of Diseases 45, 831-838.

•Lacroix, J.J., and Bezanilla, F. (2011). Control of a final gating charge transition by a hydrophobic residue in the S2 segment of a K+ channel voltage sensor. Proc Natl Acad Sci U S A 108, 6444-6449.

•Lacroix, J.J., Labro, A.J., and Bezanilla, F. (2011). Properties of deactivation gating currents in shaker channels. Biophysical Journal 100, 28-30.

•Lacroix, J., Halaszovich, C.R., Schreiber, D.N., Leitner, M.G., Bezanilla, F., Oliver, D., and Villalba-Galea, C.A. (2011). Controlling the activity of PTEN by membrane potential. Journal of Biological Chemistry 286, 17945-17953.

•Tekpli, X., Huc, L., Lacroix, J., Rissel, M., Poet, M., Noel, J., Dimanche-Boitrel, M.T., Counillon, L., and Lagadic-Gossmann, D. (2008). Regulation of Na+/H+ exchanger 1 allosteric balance by its localization in cholesterol- and caveolin-rich membrane microdomains. J Cell Physiol 216, 207-220.

•Lacroix, J., Poet, M., Huc, L., Morello, V., Djerbi, N., Ragno, M., Rissel, M., Tekpli, X., Gounon, P., Lagadic-Gossmann, D., and Counillon, L. (2008). Kinetic analysis of the regulation of the Na+/H+ exchanger NHE-1 by osmotic shocks. Biochemistry 47, 13674-13685.

•Lacroix, J., Poet, M., Maehrel, C., and Counillon, L. (2004). A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens. EMBO Reports 5, 91-96.