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Michel Baudry, PhD

Michel Baudry, PhD

Professor

Graduate College of Biomedical Sciences

mbaudry@westernu.edu

Phone: 8271

  • Education

    Engineer Degree 1971

    Ecole Polytechnique Paris, France Master Degree in Biochemistry 1972

    University Paris VII Paris, France PhD Biochemistry (cum laude) 1977

    University Paris VII Paris, France

  • Education Experience

    1978-80 Postdoctoral Research Assoc UCI & CNRS Fellow

  • Professional Experience

    1972-73 Stagiaire de Recherches, National Center for Scientific Research (CNRS)

    1973-76 Attache de Recherches CNRS

    1976-78 Charge de Recherches CNRS

    1/81-6/81 Assist. Research Psychobiologist UCI

    7/81-6/82 Assist. Research Psychobiologist & Adjunct Lecturer UCI

    6/82-6/84 Assist. Professor-in-Residence UCI

    7/84-6/89 Assoc. Professor-in-Residence UCI

    9/88-6/89 Visiting Scientist, Genentech Inc., South San Francisco, CA

    1989-1993 Associate Professor, University of Southern California

    Dept. of Biology - Section of Neurobiology

    1993-2011 Professor, USC, Dept. of Biology-Section of Neurobiology, Department of Neurology, USC Medical School, Department of Biomedical Engineering, USC.

    2001- 2003: Visiting Professor, Department of Psychiatry & Human Behavior, UCI, CA

    2001-2003: VP Research, Tensor Biosciences, Irvine, CA

    2012- 2019: Professor and Dean, Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA

    2019-present: University Professor, Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA

  • Academic Interests

    Neuroscience

    Computational Biology

    Advanced Courses

    Translational Research

    Teaching Experience

    UCI: Psychobiology: 1984-1987.

    USC: BISC306: Human Physiology BISC 421: Neurobiology BISC 524: Neuroscience BISC221: Advanced General Biology Special Topics in Neuroscience BISC104: Introduction to Physiology for non-biology majors BISC230Lg: Brain, Mind and Machines: Topics in Neuroscience

  • Teaching Experience

    UCI: Psychobiology: 1984-1987.

    USC: BISC306: Human Physiology BISC 421: Neurobiology BISC 524: Neuroscience BISC221: Advanced General Biology Special Topics in Neuroscience BISC104: Introduction to Physiology for non-biology majors BISC230Lg: Brain, Mind and Machines: Topics in Neuroscience

  • Research Interest

    1. Mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions.

    2. Regulation of glutamate receptors.

    3. Role of oxygen free radicals in central nervous system.

    4. Mechanisms underlying selective neuronal degeneration.

    5. Computational neuroscience

  • Research Grant

    Current Research Support:

    PI: NINDS: R01NS104078: Roles of UBE3A-mediated p18 regulation in synaptogenesis and synaptic plasticity. 06/15/2018-02/28/2023.

    PI: USA Med Research Mat CMD: Grant #BA170606: Optimization of a selective calpain-2 inhibitor for prolonged field care in Traumatic Brain Injury. 07/01/2019-06/30/2023.

  • Awards

    Pfizer Lecture, Institut de Recherches Cliniques de Montreal. Canada, December 1984.

    Doctor Honoris Causa, University of Provence, Marseille, France, 2010.

    USC Mellon Excellence Award for mentoring graduate students, April 2010.

  • Organizations

    American Neuroscience Society

    International Society of Neurochemistry

    ISI Highly Cited Researchers

    Fellow of the World Innovation Foundation

    American Association for the Advancement of Science

  • Committees

    Panel member: NSF " Molecular and Cellular Neurobiology ", 1983-1985.

    Panel Member: NIH: NSD-B Study Section, 2005-2009.

    Panel Member: NIH-Fogarty International, 2008-2011.

    Panel Member: NIH: F02 Review Panel, 2008-2011.

  • Publications

    Lynch, G. and Baudry, M. The biochemistry of memory: A new and specific hypothesis. Science. 224: 1057-1063, 1984.

    Morris, R.G.M., Anderson, E., Lynch, G.S. and Baudry, M. Selective impairment of learning and blockade of long-term potentiation by N-methyl-D-aspartate receptor antagonist, AP-5. Nature 319: 774-776, 1986.

    Bruce, A., Malfroy, B. and Baudry, M. ß-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic oxygen free radical scavenger. Proc. Nat. Acad. Sci. 93: 2312-2316, 1996.

    Rong, Y., Tocco, G., Doctrow, S. and Baudry, M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc. Nat. Acad. Sci. 96: 9897-9902, 1999.

    Bi, R., Foy, M. R., Vouimba, R.-M., Thompson, R.F. and Baudry, M. Cyclic changes in estrogen regulate synaptic plasticity through the MAP kinase pathway. Proc. Nat. Acad. Sci. 98: 13391:13395, 2001.

    Liu, R., Liu, Y., Bi, X., Thompson, R.F., Doctrow, S.R., Malfroy, B. and Baudry, M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase.catalase mimetics. Proc. Nat. Acad. Sci. 100: 8527-8531, 2003.

    Xu, W., Wong, T.P., Chery, N., Gaertner, T., Wang, Y.T. and Baudry, M. Calpain-mediated truncation of mGluR1a: a key step in excitotoxicity. Neuron, 53: 399-412, 2007.

    Zadran, S., Jourdi, H., Rostamiani, K., Qin, Q., Bi, X. and Baudry, M. BDNF- and EGF-mediated neuronal calpain activation through MAPK-dependent phosphorylation. J. Neurosci. 30: 1086-1095, 2010.

    Baudry, M., Bi, X., Gall, C. and Lynch, G. The biochemistry of memory: the 26-year journey of a new and specific hypothesis. Neurobiol. Learning & Memory 95: 125-133, 2011.

    Clausen, A., Xu, X., Bi, X. and Baudry, M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s disease: Protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J. Alz. Dis. 30: 183-208, 2012.

    Baudry, M. and Bi, X. Learning and memory: an emergent property of cell motility. Neurobiol. Learning & Memory. 104:64-72, 2013.

    Wang, Y., Zhu, G., Briz, V., Hsu, Y.-T., Bi, X. and Baudry, M. A molecular brake controls the magnitude of long-term potentiation. Nature Communications 5, Article number: 3051; doi: 10.1038/ ncomms4051, 2014.

    Briz, V., Liu, Y., Zhu, G., Bi, X. and Baudry, M. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J. Cell Biol. 210: 1225-1237, 2015.

    Baudry, M. and Bi, X. Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration. Trends in Neurosciences 2016 Feb 10. 39: 235-245. pii: S0166-2236(16)00020-5. doi: 10.1016/j.tins.2016.01.007, 2016.

    Wang Y, Hersheson J, Lopez D, Ben Hamad M, Liu Y, Lee K-H, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, Coutelier M, Brice A, Stevanin G, Durr A, Bi X, Houlden H and Michel Baudry M. Defects in the CAPN1 gene result in alterations in cerebellar development and in cerebellar ataxia in mice and humans. Cell Reports 16: 79-91, 2016.

    Wang, Y., Liu, Y., Lopez, D., Lee, M., Dayal, S., Hirtado, A., Bi, X. and Baudry, M. Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice. J. Neurotrauma, 34: 1-13, 2017.