Michel Baudry, PhD

Engineer Degree 1971

Ecole Polytechnique
Paris, France
Master Degree in Biochemistry 1972

University Paris VII
Paris, France
PhD Biochemistry (cum laude) 1977

University Paris VII
Paris, France

1978-80 Postdoctoral Research Assoc UCI & CNRS Fellow

1972-73 Stagiaire de Recherches, National Center for Scientific Research (CNRS)

1973-76 Attache de Recherches CNRS

1976-78 Charge de Recherches CNRS

1/81-6/81 Assist. Research Psychobiologist UCI

7/81-6/82 Assist. Research Psychobiologist & Adjunct Lecturer UCI

6/82-6/84 Assist. Professor-in-Residence UCI

7/84-6/89 Assoc. Professor-in-Residence UCI

9/88-6/89 Visiting Scientist, Genentech Inc., South San Francisco, CA

1989-1993 Associate Professor, University of Southern California

Dept. of Biology - Section of Neurobiology

1993-2011 Professor, USC, Dept. of Biology-Section of Neurobiology, Department of Neurology, USC Medical School, Department of Biomedical Engineering, USC.

2001- 2003: Visiting Professor, Department of Psychiatry & Human Behavior, UCI, CA

2001-2003: VP Research, Tensor Biosciences, Irvine, CA

2012- 2019: Professor and Dean, Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA

2019-present: University Professor, Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA

Neuroscience

Computational Biology

Advanced Courses

Translational Research

Teaching Experience

UCI: Psychobiology: 1984-1987.

USC: BISC306: Human Physiology BISC 421: Neurobiology BISC 524: Neuroscience BISC221: Advanced General Biology Special Topics in Neuroscience BISC104: Introduction to Physiology for non-biology majors BISC230Lg: Brain, Mind and Machines: Topics in Neuroscience

UCI:
Psychobiology: 1984-1987.

USC:
BISC306: Human Physiology
BISC 421: Neurobiology
BISC 524: Neuroscience
BISC221: Advanced General Biology
Special Topics in Neuroscience
BISC104: Introduction to Physiology for non-biology majors
BISC230Lg: Brain, Mind and Machines: Topics in Neuroscience

1. Mechanisms implicated in long-term synaptic potentiation and depression in hippocampus and other brain regions.

2. Regulation of glutamate receptors.

3. Role of oxygen free radicals in central nervous system.

4. Mechanisms underlying selective neuronal degeneration.

5. Computational neuroscience

Current Research Support:

PI: NINDS: R01NS104078: Roles of UBE3A-mediated p18 regulation in synaptogenesis and synaptic plasticity. 06/15/2018-02/28/2023.

PI: USA Med Research Mat CMD: Grant #BA170606: Optimization of a selective calpain-2 inhibitor for prolonged field care in Traumatic Brain Injury. 07/01/2019-06/30/2023.

Pfizer Lecture, Institut de Recherches Cliniques de Montreal. Canada, December 1984.

Doctor Honoris Causa, University of Provence, Marseille, France, 2010.

USC Mellon Excellence Award for mentoring graduate students, April 2010.

American Neuroscience Society

International Society of Neurochemistry

ISI Highly Cited Researchers

Fellow of the World Innovation Foundation

American Association for the Advancement of Science

Panel member: NSF " Molecular and Cellular Neurobiology ", 1983-1985.

Panel Member: NIH: NSD-B Study Section, 2005-2009.

Panel Member: NIH-Fogarty International, 2008-2011.

Panel Member: NIH: F02 Review Panel, 2008-2011.

Lynch, G. and Baudry, M. The biochemistry of memory: A new and specific hypothesis. Science. 224: 1057-1063, 1984.

Morris, R.G.M., Anderson, E., Lynch, G.S. and Baudry, M. Selective impairment of learning and blockade of long-term potentiation by N-methyl-D-aspartate receptor antagonist, AP-5. Nature 319: 774-776, 1986.

Bruce, A., Malfroy, B. and Baudry, M. ß-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic oxygen free radical scavenger. Proc. Nat. Acad. Sci. 93: 2312-2316, 1996.

Rong, Y., Tocco, G., Doctrow, S. and Baudry, M. EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Proc. Nat. Acad. Sci. 96: 9897-9902, 1999.

Bi, R., Foy, M. R., Vouimba, R.-M., Thompson, R.F. and Baudry, M. Cyclic changes in estrogen regulate synaptic plasticity through the MAP kinase pathway. Proc. Nat. Acad. Sci. 98: 13391:13395, 2001.

Liu, R., Liu, Y., Bi, X., Thompson, R.F., Doctrow, S.R., Malfroy, B. and Baudry, M. Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase.catalase mimetics. Proc. Nat. Acad. Sci. 100: 8527-8531, 2003.

Xu, W., Wong, T.P., Chery, N., Gaertner, T., Wang, Y.T. and Baudry, M. Calpain-mediated truncation of mGluR1a: a key step in excitotoxicity. Neuron, 53: 399-412, 2007.

Zadran, S., Jourdi, H., Rostamiani, K., Qin, Q., Bi, X. and Baudry, M. BDNF- and EGF-mediated neuronal calpain activation through MAPK-dependent phosphorylation. J. Neurosci. 30: 1086-1095, 2010.

Baudry, M., Bi, X., Gall, C. and Lynch, G. The biochemistry of memory: the 26-year journey of a new and specific hypothesis. Neurobiol. Learning & Memory 95: 125-133, 2011.

Clausen, A., Xu, X., Bi, X. and Baudry, M. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer’s disease: Protection against and interruption of progression of amyloid and tau pathology and cognitive decline. J. Alz. Dis. 30: 183-208, 2012.

Baudry, M. and Bi, X. Learning and memory: an emergent property of cell motility. Neurobiol. Learning & Memory. 104:64-72, 2013.

Wang, Y., Zhu, G., Briz, V., Hsu, Y.-T., Bi, X. and Baudry, M. A molecular brake controls the magnitude of long-term potentiation. Nature Communications 5, Article number: 3051; doi: 10.1038/ ncomms4051, 2014.

Briz, V., Liu, Y., Zhu, G., Bi, X. and Baudry, M. A novel form of synaptic plasticity in field CA3 of hippocampus requires GPER1 activation and BDNF release. J. Cell Biol. 210: 1225-1237, 2015.

Baudry, M. and Bi, X. Calpain-1 and calpain-2: the yin and yang of synaptic plasticity and neurodegeneration. Trends in Neurosciences 2016 Feb 10. 39: 235-245. pii: S0166-2236(16)00020-5. doi: 10.1016/j.tins.2016.01.007, 2016.

Wang Y, Hersheson J, Lopez D, Ben Hamad M, Liu Y, Lee K-H, Pinto V, Seinfeld J, Wiethoff S, Sun J, Amouri R, Hentati F, Baudry N, Tran J, Singleton AB, Coutelier M, Brice A, Stevanin G, Durr A, Bi X, Houlden H and Michel Baudry M. Defects in the CAPN1 gene result in alterations in cerebellar development and in cerebellar ataxia in mice and humans. Cell Reports 16: 79-91, 2016.

Wang, Y., Liu, Y., Lopez, D., Lee, M., Dayal, S., Hirtado, A., Bi, X. and Baudry, M. Protection against TBI-induced neuronal death with post-treatment with a selective calpain-2 inhibitor in mice. J. Neurotrauma, 34: 1-13, 2017.