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Miklos Peterfy, Ph.D.

Miklos Peterfy, Ph.D.

Professor of Biochemistry

College of Osteopathic Medicine of the Pacific

mpeterfy@westernu.edu

Phone: 3949

Join year: August 2016

  • Education

    PhD, Budapest University of Technology, Hungary, 1990

    BS, Budapest University of Technology, Hungary, 1986

  • Education Experience

    Assistant Research Biochemist, Department of Medicine, UCLA, 1998-2001

    Research Scientist, Amgen Inc. 1992-1998

    Postdoctoral Fellow, National Institutes of Health, Bethesda, MD, 1993

  • Teaching Experience

    Adjunct Professor, Department of Medicine, UCLA, 2013-2016

    Associate Professor, Director, Laboratory of Murine Models for Metabolic Disease, Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, 2007-2016

    Associate Professor, Department of Medicine, UCLA, 2007-2013

    Assistant Professor, Department of Medicine, UCLA, 2001-2007

  • Research Interest

    Dr. Peterfy's research interest is the genetic and molecular basis of common metabolic diseases including obesity, diabetes and dyslipidemia. His goal is to identify novel genes and mechanisms responsible for metabolic abnormalities and provide the foundation for the development of novel therapeutic approaches.

    • Genetic determinants of common metabolic diseases including dyslipidemia, diabetes, obesity and non-alcoholic fatty liver disease (NAFLD)
    • Molecular mechanisms of post-translational LPL maturation
    • Molecular determinants of insulin clearance and its role in glucose homeostasis
  • Research Grant

    Recent Grants

    NIH R01-HL127155, Role: PI, Molecular Mechanisms of Lipase Maturation and Secretion, $250,000/year, 7/1/15- 4/30/19.

    NIH P01-HL28481, Role: Co-Investigator, Molecular Genetic Approaches in Atherosclerosis Research, $120,000/year, 7/1/15 - 4/30/20

    NIH UL1TR000124, Role: PI, Reversal of Aging-Related Metabolic Dysfunction Through Immunotherapy, $10,000, 5/6/15-1/6/16

  • Publications

    Labadzhyan, A.; Cui, J.; Peterfy, M.; Guo, X.; Chen, Y.I.; Hsueh, W.A.; Rotter, J.J.; Goodarzi, M.O. (2016) Insulin Clearance is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans. PLOS ONE, 2016 Nov 15;11(11):e0166263. doi:10.1371/journal.pone.0166263.

    Sha, H.; Francisco, A.; Ehrhardt, N.; Sun, S.; Xue, Z.; Liu, L.; Guber, R.; Panhwar, M. S.; Hang, S.; Xue, B.; Brenna, J.T.; Kersten, S.; Bensadoun, A.; Peterfy, M.*; Long, Q.*; Qi, L.*. (2014) The ER-Associated degradation adapter protein Sel1L regulates triglyceride metabolizm via lipoprtein lipase. Cell Metab., 20: 458-470. *co-senior author.

    Ehrhardt, N.; Bedoya, C.; Peterfy, M. (2014) Embryonic viabilitiy, lipase deficiency, hypertriglyceridemia and neonatal lethality in a novel LMF1-deficent mouse model. Nutr. Metab. 11: 37-45.

    Mao, H.Z.; Ehrhardt, N.; Bedoya, C.; Gomez, J.A.; DeZwaan-McCabe, D.; Mungrue, I.N.; Kaufman, R.J.; Rutkowski, D.T.; Peterfy, M. (2014) Lipase Maturation Factor 1 is Induced by Endoplasmic Reticulum Stress Through Atf6a Signaling. J. Biol. Chem. 289:24417-24427.

    Hosseine, M.; Ehrhardt, N.; Weissglas-Volkov, D.; Lai, C.M,; Mao, H. Z.; Liao, J.; Nikkola, E.; Bensadouna, A.; Taskinen, M. R.; Doolittle, M. H.; Pajukanta, P.; Peterfy, M. (2012) Transgenic expression and variation of LMF1 affect LPL activity in mice and humans. Aterioscler. Thromb. Vasc. Biol., 32:1204-1210.

    Ben-Zeev, O.; Hosseini, M.; Lai, C.; Ehrhardt, N.; Cefalu, A. B.; Noto, D.; Averna, M. R.; Doolittle, M. R.; Peterfy, M. (2011) Lipase maturation factor 1 is required for endothelial lipase activity. J. Lipid, Res. 52: 1162-1169.

    Davis, R.C.; Castellani, L. W.; Hosseini, M.; Ben-Zeev, O.; Mao, H.Z.; Weinstein, M. M.; Jung, D. Y.; Jun, J. Y.; Kim, J. K.; Lusis, A. J.; Peterfy, M. (2010) Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes, 59:1616-1625.

    Doolittle, M. H.; Neher, S. B.; Ben-Zeev, O.; Ling-liao, J.; Gallagher, C. M. Hosseini, M. Yin, F.; Wong, H.; Walter, P.; Peterfy, M. (2009) Lipase Maturation Factor 1, Membrane topology and interaction with lipase proteins in the endoplasmic reticulum. J. Biol.Chem. 284: 33623-33633.

    For a complete list of Dr. Peterfy's publications, see: http://www.ncbi.nlm.nih.gov/sites/myncbi/miklos.peterfy.1/bibliography/41239313/public/?sort=date&direction=ascending