David J. Sanchez, PhD

PhD Biomedical Science University of California San Francisco 2004 BS Biochemistry University of Texas 1999

Postdoctoral Fellowship Department of Microbiology, Immunology & Molecular Genetics University of California, Los Angeles 2004-2009

My laboratory studies the immune response to viruses. While the immune system is effective in defending us against a majority of pathogens, infectious viruses bypass these defenses to establish infection. We look at the mechanisms of viral recognition that activate the innate immune system and the ways viruses block their recognition by these pathways. We have found proteins from viruses such as HIV and KSHV that can effectively block induction of Type I Interferon, the key anti-viral cytokine of the innate immune system. Development of strategies to block these viral proteins will allow effective innate immune responses against these viruses.

Principal Investigator, “Manipulation of Type I Interferon by HIV Infection” NIH, National Institute of Allergy and Infectious Diseases (NIAID), R15 program, 2018-2021.

Principal Investigator, “KSHV Modulation of Type I Interferon” NIH, National Institute of Dental and Craniofacial Research (NIDCR), R03 New Investigator program, 2013-2015.

Ding X, Krutzik PO, Ghaffari AA, Zhaozhi Y, Miranda D Jr, Cheng G, Ho CM, Nolan GP, Sanchez DJ., “Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation.” Antiviral Research, 2019 Sep 9;171:104598. doi: 10.1016/j.antiviral.2019.104598. [Epub ahead of print]

He B, Tran JT, and Sanchez DJ, “Manipulation of Type I Interferon Signaling by HIV and AIDS-Associated Viruses,” Journal of Immunology Research, vol. 2019, Article ID 8685312, 10 pages, 2019. https://doi.org/10.1155/2019/8685312

Houghton JS, Nguyen H, Casillas P, Dizon TMA, Nguyen NV, Miranda D Jr, and Sanchez DJ. (2019) Stimulation of IL-16 Release by Cells Exposed to HIV Virion Proteins. J Immunol Infect Dis 6(1): 101.

Nguyen, NV Tran, JT and Sanchez, DJ. (2018) HIV Vpu and Nef Block Type I Interferon Signaling Through Disruption of STAT1 Phosphorylation. Innate Immunity. 24(8): 490-500. 1753425918803674 doi:10.1177/1753425918803674.

Wang L, Liu S-Y, Chen H-W, Xu J, Chapon M, Zhang T, Zhou F, Wang YE, Quanquin N, Wang G, Tian X, He Z, Liu L, Yu W, Sanchez DJ, Liang Y, Jiang T, Modlin R, Bloom BR, Li Q, Deng JC, Zhou P, Qin FX-F, Cheng G., (2017) Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets. Cell Host & Microbe, 21(3):334-43. doi: 10.1016/j.chom.2017.02.007.

Sanchez DJ, Miranda D Jr, Marsden MD, Dizon TMA, Bontemps JR, Davila SJ, et al. (2015) Disruption of Type I Interferon Induction by HIV Infection of T Cells. PLoS ONE 10(9): e0137951. doi:10.1371/journal.pone.0137951

Liu SY, Sanchez DJ, Cheng G. New developments in the induction and antiviral effectors of type I Interferon. Curr Opin Immunol. 2011 Feb: 23(1): 57-64. Epub 2010 Nov 29. Review

Sanchez DJ, Ding X, Schopf E, Liu Y, Deng JC,Yang S, Cheng Y, Ho CM, Cheng G. Harnessing Nanotechnology to Create New Diagnostics and Treatments for Infectious Disease. Nanotechnology (IEEE-NANO), 2010 10th IEEE Conference on August 2010: 75-79.

Sanchez DJ, Miranda D Jr, Arumugaswami V, Hwang S, Singer AE, Senaati A, Shahangian A, Song MJ, Sun R, Cheng G. A repetitive region of gammaherpesvirus genomic DNA is aligand for induction of typeI interferon. J Virol. 2008 Mar;82(5):2208-17.Epub2007 Dec12.

Renn CN, Sanchez DJ, Legaspo AJ, Sieling PA, Cheng G, Modlin, RL. Function of Langerhans cell-like dendritic cells in antiviral immunity of the skin. J Immunol. 2006 Jul1;177(1):298-305.

Sanchez DJ, Gumperz JE, Ganem D. Regulation of CD1d display and function by a herpesviral infection. J Clinical Investigation. 115:1369-1378(2005).