Sebastien Fuchs, PhD
Assistant Professor of Pharmacology
College of Osteopathic Medicine of the Pacific
Join year: August 2013
M.D., University Paris VI / European Hospital Georges Pompidou, Paris, France, 2003
Ph.D., University Paris VII / College de France, Paris, France, 2002
M.S., Biochemistry, University Paris V, Paris, France, 1993
Postdoctoral Fellowship, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 2002-2006
Predoctoral and Doctoral Training, Vascular Pathology and Renal Endocrinology, INSERM U36 – Collège de France, Paris, France, 1991-2002
Student rotation in Mouse Transgenesis, Department of Molecular Genetics, MD Anderson Cancer Center, Houston, TX, Summer 1994
- Since 2013 Assistant Professor of Pharmacology Department of Basic Medical Sciences Western University of Health Sciences College of Osteopathic Medicine of the Pacific
- 2008-2013 Assistant Professor Department of Biomedical Sciences and Department Pathology and Laboratory Medicine Cedars-Sinai Medical Center (Los Angeles, CA)
- 2006-2008 Instructor Department of Pathology and Laboratory Medicine Emory University (Atlanta, GA)
- 1997-1998 Military Physician, officer. (National Defense Bronze Medal) French Army
- 1994-1996 Hospital practice: residency and internship in multiple hospitals in Paris France
- 2012 – present Academic Editor for PlosOne
Assistant Professor of Pharmacology, Western University of Health Sciences, COMP, Dept. of BMS, 2013-present
Assistant Professor, Department of Biomedical Sciences and Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 2008-2012
Instructor, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, 2006- 2008
Cardiovascular System (CARDIO)
Renal System (RENAL)
Respiratory System (RESP)
Reproductive System (REPRO)
I am studying the biochemistry and physiology of Angiotensin-Converting Enzyme (ACE) in vivo in genetically modified animals. Beside blood pressure, ACE is involved in many other function including peptide presentation (immunology), extracellular matrix control (end-organ damages), male fertility, Alzheimer's disease.
My current areas of research are organ fibrosis (inflammation and extracellular matrix processing) and Alzheimer's disease.
I have acquired numerous scientific/technical skills (molecular biology: DNA manipulation, mutation, plasmid construction and analysis, animal genetic models, biochemistry, cellular biology, in vivo experimentation, animal physiology).
I have a special interest for promoting students' research.
The CART Fund for Alzheimer Research. Award, 2012-2014 RO0 phase of NIH/NHLBI Pathway to Independence Award (K99/RO0 HL088000), 2008-2011 K99 phase of NIH/NHLBI Pathway to Independence Award (K99/RO0 HL088000), 2006-2008 Beginning Grant in Aid from the “American Heart Association” (0665176B), 2006-2008 Research fellowship from the “National Kidney Foundation”, 2004-2006 Grant for foreign post-doctoral fellowship from INSERM, 2002-2003 Grant fellowship from “Academie Nationale de medecine”, 2001-2002 Doctoral fellowship from the French Ministry for Scientific Research, 1998-2001 Predoctoral fellowship from “Fondation pour la Recherche Medicale”, 1997-1998 Fellowship for foreign training program from “Fondation pour la Recherche, Medicale”, 1994
- Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA. (2016) Renal tublular ACE is responsible for L-NAME-induced salt sensitivity. Kidney International. 2016 Dec 14. pii S0085-2538(16)30606-8. doi: 10.1016/j.kint.2016.10.007.
- Giani JF., Janjulia T., Kamat N., Seth DM., Blackwell WL., Shah KH., Shen ZS., Fuchs S., Delpire E., Toblli JE., Bernstein KE., McDonough AA. and Gonzalez-Villalobos RA. Renal Angiotensin-Converting Enzyme Is Essential for the Hypertension Induced by Nitric Oxide Synthesis Inhibition. J Am Soc Nephrol. 2014 Dec;25(12):2752-63.
- Bernstein KE., Koronyo Y., Salumbides B., Sheyn J. Pelissier L., Lopes DHJ., Shah KH., Bernstein EA., Fuchs DT., Yu J., Pham M., Black KL., Xiao ZH., Fuchs S. and Koronyo-Hamaoui M. Angiotensin-converting enzyme overexpression in myelomonocytes prevents Alzheimer’s-like cognitive decline. J Clin Invest. 2014;124(3):1000–1012.
- Gonzalez-Villalobos RA., Jandjoulia T., Fletcher NK., Giani JF., Nguyen MT., Riquier-Brison AD., Seth DM., Fuchs S., Eladari D., Picard N., Bachmann S., Delpire E., Peti-Peterdi J., Navar LG., Bernstein KE. and McDonough AA. The absence of intrarenal ACE protects against hypertension. J Clin Invest.2013, May 1;123(5):2011-2023
- Bernstein KE., Ong FS., Blackwell WB., Shah KH., Giani JF., Gonzalez-Villalobos RA., Shen XZ., Fuchs S. A modern understanding of the traditional and non-traditional biological functions of angiotensin converting enzyme (ACE). Pharmacol Rev, 2012 Dec 20;65(1):1-46.
- Shen XZ., Ong FS., Bernstein EA., Janjulia T., Blackwell WL., Shah KH., Taylor BL., Gonzalez-Villalobos RA., Fuchs S., Bernstein KE. Nontraditional roles of angiotensin-converting enzyme. Hypertens. 2012 Apr;59(4):763-8.
- Ong FS., Lin CX., Campbell DJ., Okwan-Duodu D., Chen X., Blackwell WLB., Shah KH., Gonzalez-Villalobos RA., Shen, XZ. and Fuchs S., Bernstein KE. Increased angiotensin II induced hypertension and inflammatory cytokines in mice lacking angiotensin converting enzyme N-domain activity. Hypertens. 2012 Feb;59(2):283-90.
- Bernstein KE, Shen XZ, Gonzalez-Villalobos RA, Billet S, Okwan-Duodu D, Ong FS, and Fuchs S. Different in vivo functions of the two catalytic domains of angiotensin converting enzyme (ACE). Curr Opin Pharmacol. 2011 Apr;11(2):105-11.
- Gonzalez-Villalobos RA, Billet S, Kim C, Satou R, Fuchs S, Bernstein KE, and Navar LG. Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion. J Am Soc Nephrol. 2011 Mar;22(3):449-59.
- Okwan-Duodu D, Datta V, Shen XZ, Goodridge HS, Bernstein EA, Fuchs S, Liu GY, and Bernstein KE. Angiotensin-converting enzyme overexpression in mouse myelomonocytic cells augments resistance to Listeria and methicillin-resistant Staphylococcus aureus. J Biol Chem. 2010 Dec 10;285(50):39051-60
- Li P, Xiao HD, Xu J, Ong FS, Kwon M, Roman J, Gal A, Bernstein KE, and Fuchs S. Angiotensin-converting enzyme N-terminal inactivation alleviates bleomycin-induced lung injury. Am J Pathol. 2010 Sep; 177 (3) :1113-21.
Invited Talks and Abstracts
- S. Fuchs. “Angiotensin-Independent Functions of Angiotensin-Converting Enzyme” XX Brazilian Society Congress of Hypertension, August 2012, Sao Paulo, Brazil (invited speaker)
- S. Fuchs, P. Li, RA. Gonzalez-Villalobos, KE. Bernstein. “Importance of the N-terminal site of angiotensin-converting enzyme and AcSDKP in the control of fibrosis” Gordon Research Conference, 2012 February 26 - March 2, 2012, Ventura, CA, (poster).
- S. Fuchs, P. Li, RA. Gonzalez-Villalobos, KE. Bernstein. “The tetrapeptide SDKP protects from bleomycin-induced lung injury.” Gordon Research Conference, August 14-19, 2011, Newport, RI. (poster).
- S. Fuchs “Importance of the N-terminal site of angiotensin-converting enzyme and AcSDKP in the control of fibrosis” Experimental Biology 2011, April 10, 2011, Washington DC, (invited speaker).
- S. Fuchs “ACE inactivation to treat lung fibrosis? Lessons from animal models” BATSSS, April 7, 2010, Cedars-Sinai Medical Center, Los Angeles, CA. (poster).